Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …

The incidence of diabetes has been increasing in recent decades which is affecting the
population of both, developed and developing countries. Diabetes is associated with micro …

Introduction Drugs targeting mitochondria are emerging as promising antitumor therapeutics
in preclinical models. However, a few of these drugs have shown clinical toxicity …

Background Mild-temperature photothermal therapy (mild-PTT) has emerged as a highly
promising antitumor strategy by triggering immunogenic cell death (ICD) to elicit both innate …

Currently, there is increasing evidence linking diabetes mellitus (especially type 2 diabetes
mellitus) with carcinogenesis through various biological processes, such as fat-induced …

Highlights•Discovery of new drugs against cancer is of utmost importance.•Drug repurposing
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …

Cells adapt to nutrient and energy deprivation by inducing autophagy, which is regulated by
the mammalian target of rapamycin (mTOR) and AMP-activated protein kinases (AMPKs) …

Mitochondria are generally considered the powerhouse of the cell, a small subcellular
organelle that produces most of the cellular energy in the form of adenosine triphosphate …

Genomics has contributed to the treatment of a fraction of cancer patients. However, there is
a need to profile the proteins that define the phenotype of cancer and its pathogenesis. The …

Abstract Aldehyde dehydrogenase 3A1 (ALDH3A1) is an NAD+-dependent enzyme that is
closely related to tumor development. However, its role in non-small-cell lung cancer …