[HTML][HTML] Targeting epigenetics in diabetic cardiomyopathy: Therapeutic potential of flavonoids

Y Zhou, W Suo, X Zhang, Y Yang, W Zhao, H Li… - Biomedicine & …, 2023 - Elsevier
The pathophysiological mechanisms of diabetic cardiomyopathy have been extensively
studied, but there is still a lack of effective prevention and treatment methods. The ability of …

An update in epigenetics in metabolic-associated fatty liver disease

JS Rodríguez-Sanabria, R Escutia-Gutiérrez… - Frontiers in …, 2022 - frontiersin.org
Metabolic-associated fatty liver disease (MAFLD) is characterized by hepatic steatosis
accompanied by one of three features: overweight or obesity, T2DM, or lean or normal …

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

SR Mihaylov, LM Castelli, YH Lin, A Gül, N Soni… - Nature …, 2023 - nature.com
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism
homeostasis, linking external stimuli to transcriptional co-activation of genes involved in …

Dietary flavonoids prevent diabetes through epigenetic regulation: advance and challenge

S Han, Y Luo, B Liu, T Guo, D Qin… - Critical Reviews in Food …, 2023 - Taylor & Francis
The pathophysiology of diabetes has been studied extensively in various countries, but
effective prevention and treatment methods are still insufficient. In recent years, epigenetics …

Transcriptome and DNA methylation responses in the liver of yellowfin seabream under starvation stress

YL Lin, ZX Zhu, CH Ai, YY Xiong, T De Liu, HR Lin… - Marine …, 2023 - Springer
Fish suffer from starvation due to environmental risks such as extreme weather in the wild
and due to insufficient feedings in farms. Nutrient problems from short-term or long-term …

[HTML][HTML] Molecular Basis of Cardiomyopathies in Type 2 Diabetes

S Giardinelli, G Meliota, D Mentino, G D'Amato… - International Journal of …, 2024 - mdpi.com
Diabetic cardiomyopathy (DbCM) is a common complication in individuals with type 2
diabetes mellitus (T2DM), and its exact pathogenesis is still debated. It was hypothesized …

Preexisting type 1 diabetes mellitus blunts the development of posttraumatic osteoarthritis

ND Rios Arce, DK Murugesh, NR Hum… - Journal of Bone and …, 2022 - academic.oup.com
Type 1 diabetes mellitus (T1DM) affects 9.5% of the population. T1DM is characterized by
severe insulin deficiency that causes hyperglycemia and leads to several systemic effects …

Diabetic hearts exhibit global DNA Hypermethylation that alter the mitochondrial functional genes to enhance the sensitivity of the heart to ischemia reperfusion injury

SR Boovarahan, DR Chellappan, N Ali, AF AlAsmari… - Biomedicines, 2022 - mdpi.com
A recent study has shown that DNA hypermethylation can promote ischemia reperfusion
(I/R) injury by regulating the mitochondrial function. Diabetes mellitus (DM) is reported to …

[HTML][HTML] Effects of carnosic acid on mitochondrial biogenesis and insulin sensitivity in 3T3-L1 adipocytes are through induction of PGC-1α and ubiquitination of PARIS …

CY Lin, YH Cheng, CN Lai, CW Tsai - Journal of Functional Foods, 2023 - Elsevier
The PGC-1α plays a vital role in regulating mitochondrial biogenesis and insulin sensitivity.
This study investigated the role of PGC-1α in preventing the effects of carnosic acid (CA) …

[HTML][HTML] Unraveling epigenetic signatures for early detection of diabetes nephropathy in type 2 diabetes: A case–Control investigation

D Chahar, GK Sonkar, S Singh… - Biomedical and …, 2024 - journals.lww.com
Background: Type 2 diabetes mellitus (T2DM) leads to a substantial elevation in the
occurrence of various micro-and macrovascular complications. Approximately one-third of …