Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair

E Bolderson, DJ Richard, BBS Zhou, KK Khanna - Clinical Cancer Research, 2009 - AACR
Damage to genetic material represents a persistent and ubiquitous threat to genomic
stability. Once DNA damage is detected, a multifaceted signaling network is activated that …

Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance

W Henning, HW Stürzbecher - Toxicology, 2003 - Elsevier
We provide an overview of the functional interrelationship between genes and proteins
related to DNA repair by homologous recombination and cell cycle regulation in relation to …

[HTML][HTML] BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

A Slupianek, C Schmutte, G Tombline… - Molecular cell, 2001 - cell.com
RAD51 is one of six mitotic human homologs of the E. coli RecA protein (RAD51-Paralogs)
that play a central role in homologous recombination and repair of DNA double-strand …

RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

B Budke, HL Logan, JH Kalin… - Nucleic acids …, 2012 - academic.oup.com
Homologous recombination serves multiple roles in DNA repair that are essential for
maintaining genomic stability. We here describe RI-1, a small molecule that inhibits the …

p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

C Arias‐Lopez, I Lazaro‐Trueba, P Kerr, CJ Lord… - EMBO …, 2006 - embopress.org
DNA repair by homologous recombination is involved in maintaining genome stability.
Previous data report that wild‐type p53 suppresses homologous recombination and …

Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G2/M phase, and protection from …

A Slupianek, G Hoser, I Majsterek… - … and cellular biology, 2002 - Am Soc Microbiol
Fusion tyrosine kinases (FTKs) such as BCR/ABL, TEL/ABL, TEL/JAK2, TEL/PDGFβR,
TEL/TRKC (L), and NPM/ALK arise from reciprocal chromosomal translocations and cause …

Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity

JS Russell, K Brady, WE Burgan, MA Cerra, KA Oswald… - Cancer research, 2003 - AACR
Rad51 is an essential component of the homologous DNA repair pathway and has been
implicated as a determinant of cellular radiosensitivity. Gleevec is a relatively specific …

Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors

SJ Collis, MJ Swartz, WG Nelson, TL DeWeese - Cancer research, 2003 - AACR
Recent developments in the use of small inhibitory RNA molecules (siRNAs) to inhibit
specific protein expression have highlighted the potential use of siRNA as a therapeutic …

FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA-Repair Gene Rad51

N Zhang, X Wu, L Yang, F Xiao, H Zhang, A Zhou… - Clinical cancer …, 2012 - AACR
Purpose: Recurrent glioblastoma multiforme (GBM) is characterized by resistance to
radiotherapy and chemotherapy and a poor clinical prognosis. In this study, we investigated …

BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability

T Skorski - Oncogene, 2002 - nature.com
BCR/ABL regulates cell proliferation, apoptosis, differentiation and adhesion. In addition,
BCR/ABL can induce resistance to cytostatic drugs and irradiation by modulation of DNA …