Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells

M Sarsenova, Y Kim, K Raziyeva, B Kazybay… - Frontiers in …, 2022 - frontiersin.org
Considering the unique therapeutic potential of mesenchymal stem cells (MSCs), including
their immunosuppressive and immunomodulatory properties as well as their ability to …

Diabetic cardiomyopathy: Early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions

JL Huo, Q Feng, S Pan, WJ Fu, Z Liu, Z Liu - Cell death discovery, 2023 - nature.com
Diabetic cardiomyopathy (DCM) mainly refers to myocardial metabolic dysfunction caused
by high glucose, and hyperglycemia is an independent risk factor for cardiac function in the …

Guidelines on models of diabetic heart disease

LC Heather, AD Hafstad, GV Halade… - American Journal …, 2022 - journals.physiology.org
Diabetes is a major risk factor for cardiovascular diseases, including diabetic
cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular …

[HTML][HTML] Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt/mTOR activation

F Du, M Liu, J Wang, L Hu, D Zeng, S Zhou, L Zhang… - Metabolism, 2023 - Elsevier
Introduction Cell therapy with mesenchymal stem cells (MSCs) and biomaterials holds great
potential for the treatment of diabetic ulceration; however, the underlying mechanism as well …

State of the field: cellular and exosomal therapeutic approaches in vascular regeneration

EP Tracy, V Stielberg, G Rowe… - American Journal …, 2022 - journals.physiology.org
Pathologies of the vasculature including the microvasculature are often complex in nature,
leading to loss of physiological homeostatic regulation of patency and adequate perfusion to …

Endothelial Cells Promote Migration of Mesenchymal Stem Cells via PDGF‐BB/PDGFRβ‐Src‐Akt in the Context of Inflammatory Microenvironment upon Bone Defect

S He, T Hou, J Zhou, Q Ai, C Dou, F Luo… - Stem Cells …, 2022 - Wiley Online Library
Homing of mesenchymal stem cells (MSCs) to the defect site is indispensable for bone
repair. Local endothelial cells (ECs) can recruit MSCs; however, the mechanism remains …

Mesenchymal stem cells therapies on fibrotic heart diseases

F Gubert, JS da Silva, JF Vasques… - International journal of …, 2021 - mdpi.com
Stem cell therapy is a promising alternative approach to heart diseases. The most prevalent
source of multipotent stem cells, usually called somatic or adult stem cells (mesenchymal …

Mesenchymal stem cell therapy in diabetic cardiomyopathy

JS da Silva, RGJ Gonçalves, JF Vasques, BS Rocha… - Cells, 2022 - mdpi.com
The incidence and prevalence of diabetes mellitus (DM) are increasing worldwide, and the
resulting cardiac complications are the leading cause of death. Among these complications …

[HTML][HTML] Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications

XM Hu, Q Zhang, RX Zhou, YL Wu, ZX Li… - World Journal of Stem …, 2021 - ncbi.nlm.nih.gov
Stem cell-based therapy raises hopes for a better approach to promoting tissue repair and
functional recovery. However, transplanted stem cells show a high death percentage …

Targeting programmed cell death to improve stem cell therapy: implications for treating diabetes and diabetes-related diseases

Q Zhang, XX Wan, XM Hu, WJ Zhao, XX Ban… - Frontiers in Cell and …, 2021 - frontiersin.org
Stem cell therapies have shown promising therapeutic effects in restoring damaged tissue
and promoting functional repair in a wide range of human diseases. Generations of insulin …