Knowledge of protein structure is paramount to the understanding of biological function,
developing new therapeutics, and making detailed mechanistic hypotheses. Therefore …

The determination of membrane protein (MP) structures has always trailed that of soluble
proteins due to difficulties in their overexpression, reconstitution into membrane mimetics …

Essential processes in biology are carried out by large macromolecular assemblies, whose
structures are often difficult to determine by traditional methods. Increasingly, researchers …

Structures of biomolecular systems are increasingly computed by integrative modeling. In
this approach, a structural model is constructed by combining information from multiple …

Prediction of protein structures using computational approaches has been explored for over
two decades, paving a way for more focused research and development of algorithms in …

Prediction of protein tertiary structures from amino acid sequence and understanding the
mechanisms of how proteins fold, collectively known as “the protein folding problem,” has …

Recent development of high-resolution mass spectrometry (MS) instruments enables
chemical crosslinking (XL) to become a high-throughput method for obtaining structural …

A variety of techniques involving the use of mass spectrometry (MS) have been developed to
obtain structural information on proteins and protein complexes. One example of these …

Despite advances in sampling and scoring strategies, Monte Carlo modeling methods still
struggle to accurately predict de novo the structures of large proteins, membrane proteins, or …

Computational methods to predict protein structure from nuclear magnetic resonance (NMR)
restraints that only require assignment of backbone signals, hold great potential to study …