We review the recent biomedical detection developments of scanning near-field optical
microscopy (SNOM), focusing on scattering-type SNOM, atomic force microscope-based …

Despite the ubiquitous absorption of mid-infrared (IR) radiation by virtually all molecules that
belong to the major biomolecules groups (proteins, lipids, carbohydrates, nucleic acids), the …

Infrared spectroscopic imaging is widely used for the visualization of biomolecule structures,
and techniques such as optical photothermal infrared (OPTIR) microspectroscopy can …

This tutorial reviews the rapidly growing field of optical photothermal infrared (O-PTIR)
spectroscopy and chemical imaging. O-PTIR is an infrared super-resolution measurement …

The use of vibrational spectroscopy to probe environmental samples is increasing with the
development of new methods, including microspectroscopic probes. In this study, we …

Background and aims Reduced bone mineral density (BMD) and microarchitectural
deterioration contribute to increased fracture risk. Although the effects of anti-fracture …

Understanding the composition of bone tissue at the submicron level is crucial to elucidate
factors contributing to bone disease and fragility. Here, we introduce a novel approach …

The molecular basis of bone structure and strength is mineralized collagen fibrils at the
submicron scale (∼ 500 nm). Recent advances in optical photothermal infrared (O-PTIR) …

We present vibrational sum-frequency generation (VSFG) microscopy as a new label-free
chemical imaging technique for tumor identification. This method combines the chemical …