Towards clinical translation of FLASH radiotherapy
MC Vozenin, J Bourhis, M Durante - Nature Reviews Clinical Oncology, 2022 - nature.com
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
Ultra‐high dose rate dosimetry: challenges and opportunities for FLASH radiation therapy
F Romano, C Bailat, PG Jorge, MLF Lerch… - Medical …, 2022 - Wiley Online Library
The clinical translation of FLASH radiotherapy (RT) requires challenges related to dosimetry
and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors …
and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors …
Ultra‐high dose rate electron beams and the FLASH effect: from preclinical evidence to a new radiotherapy paradigm
In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …
Quantification of oxygen depletion during FLASH irradiation in vitro and in vivo
Purpose Delivery of radiation at ultrahigh dose rates (UHDRs), known as FLASH, has
recently been shown to preferentially spare normal tissues from radiation damage compared …
recently been shown to preferentially spare normal tissues from radiation damage compared …
FLASH: New intersection of physics, chemistry, biology, and cancer medicine
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …
innovations over the past decade in the field of radiation oncology, with the potential to …
The current status of preclinical proton FLASH radiation and future directions
ES Diffenderfer, BS Sørensen, A Mazal… - Medical …, 2022 - Wiley Online Library
We review the current status of proton FLASH experimental systems, including preclinical
physical and biological results. Technological limitations on preclinical investigation of …
physical and biological results. Technological limitations on preclinical investigation of …
Establishment and initial experience of clinical FLASH radiotherapy in canine cancer patients
E Konradsson, ML Arendt, K Bastholm Jensen… - Frontiers in …, 2021 - frontiersin.org
FLASH radiotherapy has emerged as a treatment technique with great potential to increase
the differential effect between normal tissue toxicity and tumor response compared to …
the differential effect between normal tissue toxicity and tumor response compared to …
FLASH radiotherapy with photon beams
Ultra‐high‐dose rate “FLASH” radiotherapy (FLASH‐RT) has been shown to drastically
reduce normal tissue toxicities while being as efficacious as conventional dose rate …
reduce normal tissue toxicities while being as efficacious as conventional dose rate …
[HTML][HTML] Framework for quality assurance of ultrahigh dose rate clinical trials investigating FLASH effects and current technology gaps
Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …
[HTML][HTML] FLASH radiotherapy treatment planning and models for electron beams
M Rahman, A Trigilio, G Franciosini, R Moeckli… - Radiotherapy and …, 2022 - Elsevier
The FLASH effect designates normal tissue sparing at ultra-high dose rate (UHDR,> 40
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …