Malaria is an infectious disease and a serious public health problem in the world, with 3.3
billion people in endemic areas in 100 countries and about 200 million new cases each …

The mechanism of action of artemisinin and its derivatives, the most potent of the anti-
malarial drugs, is not completely understood. Here we present an unbiased chemical …

Malaria, as one of the most common human infectious diseases, remains the greatest global
health concern, since approximately 3.5 billion people around the world, especially those in …

Neutrophils are essential innate immune cells that extrude chromatin in the form of
neutrophil extracellular traps (NETs) when they die. This form of cell death has potent …

The Propagation of Plasmodium spp. and Babesia/Theileria spp. vertebrate blood stages
relies on the mediated acquisition of nutrients available within the host's red blood cell …

Apicomplexa are unicellular eukaryotes that parasitise a wide spectrum of invertebrates and
vertebrates, including humans. In their hosts, they occupy a variety of niches, from …

Obligate intracellular parasites have evolved a remarkable assortment of strategies to
scavenge nutrients from the host cells they parasitize. Most apicomplexans form a …

Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired
as high-value partners for combination therapies. Here, we report the identification and …

Malaria, caused by parasites of the species Plasmodium, is among the major life-threatening
diseases to afflict humanity. The infectious cycle of Plasmodium is very complex involving …

The loss of key biosynthetic pathways is a common feature of important parasitic protists,
making them heavily dependent on scavenging nutrients from their hosts. This is often …