Autophagy is emerging as a crucial defense mechanism against bacteria, but the host intracellular sensors responsible for inducing autophagy in response to bacterial infection …
MH Shaw, T Reimer, YG Kim, G Nuñez - Current opinion in immunology, 2008 - Elsevier
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR)(nucleotide- binding domain leucine-rich repeat containing) family of proteins has been demonstrated to …
JPY Ting, JA Duncan, Y Lei - Science, 2010 - science.org
NLR (nucleotide-binding domain, leucine-rich repeat–containing) proteins have rapidly emerged as central regulators of immunity and inflammation with demonstrated relevance to …
NOD1 {nucleotide-binding oligomerization domain 1; NLRC [NOD-LRR (leucine-rich repeat) family with CARD (caspase recruitment domain) 1]} and NOD2 (NLRC2) are among the …
Members of the family of NOD-like receptors (NLRs) play essential roles in innate immunity by detecting intracellular 'pathogen-associated molecular patterns'(PAMPs) and 'danger …
JT Tigno-Aranjuez, JM Asara… - Genes & …, 2010 - genesdev.cshlp.org
Upon intracellular bacterial exposure, the Crohn's disease and sarcoidosis susceptibility protein NOD2 (nucleotide oligomerization domain protein 2) binds to the protein kinase …
Cellular stress has been associated with inflammation, yet precise underlying mechanisms remain elusive. In this study, various unrelated stress inducers were employed to screen for …