NOD1 and NOD2 in inflammatory and infectious diseases

BC Trindade, GY Chen - Immunological reviews, 2020 - Wiley Online Library
It has been long recognized that NOD1 and NOD2 are critical players in the host immune
response, primarily by their sensing bacterial peptidoglycan‐conserved motifs. Significant …

Functions of NOD-like receptors in human diseases

Y Zhong, A Kinio, M Saleh - Frontiers in immunology, 2013 - frontiersin.org
Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

LH Travassos, LAM Carneiro, M Ramjeet… - Nature …, 2010 - nature.com
Autophagy is emerging as a crucial defense mechanism against bacteria, but the host
intracellular sensors responsible for inducing autophagy in response to bacterial infection …

NOD-like receptors (NLRs): bona fide intracellular microbial sensors

MH Shaw, T Reimer, YG Kim, G Nuñez - Current opinion in immunology, 2008 - Elsevier
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR)(nucleotide-
binding domain leucine-rich repeat containing) family of proteins has been demonstrated to …

How the noninflammasome NLRs function in the innate immune system

JPY Ting, JA Duncan, Y Lei - Science, 2010 - science.org
NLR (nucleotide-binding domain, leucine-rich repeat–containing) proteins have rapidly
emerged as central regulators of immunity and inflammation with demonstrated relevance to …

Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases

RG Correa, S Milutinovic, JC Reed - Bioscience reports, 2012 - portlandpress.com
NOD1 {nucleotide-binding oligomerization domain 1; NLRC [NOD-LRR (leucine-rich repeat)
family with CARD (caspase recruitment domain) 1]} and NOD2 (NLRC2) are among the …

NOD-like receptors and the innate immune system: coping with danger, damage and death

K Kersse, MJM Bertrand, M Lamkanfi… - Cytokine & growth factor …, 2011 - Elsevier
Members of the family of NOD-like receptors (NLRs) play essential roles in innate immunity
by detecting intracellular 'pathogen-associated molecular patterns'(PAMPs) and 'danger …

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses

JT Tigno-Aranjuez, JM Asara… - Genes & …, 2010 - genesdev.cshlp.org
Upon intracellular bacterial exposure, the Crohn's disease and sarcoidosis susceptibility
protein NOD2 (nucleotide oligomerization domain protein 2) binds to the protein kinase …

Cellular stress promotes NOD1/2‐dependent inflammation via the endogenous metabolite sphingosine‐1‐phosphate

G Pei, J Zyla, L He, P Moura‐Alves, H Steinle… - The EMBO …, 2021 - embopress.org
Cellular stress has been associated with inflammation, yet precise underlying mechanisms
remain elusive. In this study, various unrelated stress inducers were employed to screen for …

Plant intracellular innate immune receptor Resistance to Pseudomonas syringae pv. maculicola 1 (RPM1) is activated at, and functions on, the plasma membrane

Z Gao, EH Chung, TK Eitas… - Proceedings of the …, 2011 - National Acad Sciences
Plants deploy intracellular innate immune receptors to recognize pathogens and initiate
disease resistance. These nucleotide-binding, leucine-rich repeat (NB-LRR) proteins are …