The potential role of gossypetin in the treatment of diabetes mellitus and its associated complications: a review

K Naidoo, A Khathi - International Journal of Molecular Sciences, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a metabolic disorder caused by insulin resistance and
dysfunctional beta (β)-cells in the pancreas. Hyperglycaemia is a characteristic of …

The potential of flavonoids in hepatic fibrosis: a comprehensive review

Z Wenbo, H Jianwei, L Hua, T Lei, C Guijuan… - Phytomedicine, 2024 - Elsevier
Background Hepatic fibrosis is a pathophysiological process of extracellular matrix
abnormal deposition induced by multiple pathogenic factors. Currently, there is still a lack of …

[HTML][HTML] Effects of Gossypetin on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats

K Naidoo, A Khathi - Molecules, 2024 - mdpi.com
Natural flavonoids exert many potential health benefits, including anti-hyperglycaemic
effects. However, the effects of gossypetin (GTIN) on glucose homeostasis in pre-diabetes …

Experimental study on H2O2 activation of HSC-T6 and hepatic fibrosis in cholestatic mice by" Yajieshaba"

Y Bai, F Liu, S Luo, Y Wan, L Zhang, X Wu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Yajieshaba (YJSB), approved by the Yunnan Provincial
Food and Drug Administration in 2008, are known for their anti-inflammatory, antiviral, and …

Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice

C Xu, H Tai, Y Chu, Y Liu, J He, Y Wang… - Frontiers in …, 2024 - frontiersin.org
Liver fibrosis occurs in response to chronic damage and inflammation to the liver. Leaving
untreated, it can lead to decreased liver function and can eventually progress to cirrhosis, a …

Flavonoid gossypetin protects alveolar bone and limits inflammation in ligature‐induced periodontitis in mice

J Seok, MO Kim, SH Kim, KY Ryu, JY Kim… - Journal of …, 2024 - Wiley Online Library
Background Bacterial‐induced inflammation instigates the destruction of hard and soft
tissues surrounding teeth in periodontitis. In severe cases, the increased number and activity …

[HTML][HTML] Investigating the Effects of Gossypetin on Cardiovascular Function in Diet-Induced Pre-Diabetic Male Sprague Dawley Rats

K Naidoo, A Khathi - International Journal of Molecular Sciences, 2024 - mdpi.com
Gossypetin (GTIN) is a naturally occurring flavonoid recognised for its pharmacological
properties. This study examined the effects of GTIN on cardiovascular function in a diet …