Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

One of the recently emerging topics in biotechnology is natural receptors including G protein-
coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular …

We have developed a novel, all-electronic biosensor for opioids that consists of an
engineered μ-opioid receptor protein, with high binding affinity for opioids, chemically …

Membrane proteins play crucial roles in cellular processes and are often important
pharmacological drug targets. The hydrophobic properties of these proteins make full …

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …

Structure and function studies of membrane proteins, particularly G protein-coupled
receptors and multipass transmembrane proteins, require detergents. We have devised a …

The nicotinic acetylcholine receptor (nAChR) is a transmembrane protein that mediates fast
intercellular communication in response to the endogenous neurotransmitter acetylcholine …

Membrane proteins are critical to biological processes and central to life sciences and
modern medicine. However, membrane proteins are notoriously challenging to study, mainly …

Background Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical
transmission of nerve signals in the central and peripheral nervous system. On the functional …

G-protein-coupled receptors (GPCRs) play essential roles in various physiological
processes, and are widely targeted by pharmaceutical drugs. Despite their importance …