In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

Nucleic acids are excellent at recognizing complementary sequences through the formation
of Watson− Crick base pairs. Since the base pairing enables the highly selective …

C‐rich DNA has the capacity to form a tetra‐stranded structure known as an i‐motif. The i‐
motifs within genomic DNA have been proposed to contribute to the regulation of DNA …

G-rich sequences in DNA and RNA have a propensity to fold into stable secondary
structures termed G-quadruplexes. G-quadruplex forming sequences are widespread …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

G-rich DNA and RNA sequences can form four-stranded structures called G-quadruplexes.
Such structures have gained significant interest in the past decade with increasing evidence …

Classical structural biology approaches allow structural characterization of biological
macromolecules in vitro, far from their physiological context. Nowadays, thanks to the wealth …

The tertiary structure and conformational dynamics of ribonucleic acids (RNAs) are essential
for their function as biological catalysts, regulators, and structural scaffolds.[1] X-ray …