Endothelial dysfunction contributes to cardiovascular diseases, including hypertension,
atherosclerosis, and coronary artery disease, which are also characterized by insulin …

Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Chemical processes can be described by detailed kinetic reaction mechanisms consisting of
several hundreds or even thousands of reaction steps. Such reaction mechanisms are used …

Abstract Type 2 diabetes (T2DM) results when increases in beta cell function and/or mass
cannot compensate for rising insulin resistance. Numerous studies have documented the …

“Natural selection can preserve innovations, but it cannot create them. Nature's many
innovations—some uncannily perfect—call for natural principles that accelerate life's ability …

Advances in biotechnology and experimental techniques have lead to the elucidation of vast
amounts of biological data. Mathematical models provide a method of analysing this data; …

Integration of experimental studies with mathematical modeling allows insight into systems
properties, prediction of perturbation effects and generation of hypotheses for further …

Previously, we have used mathematical modeling to gain mechanistic insights into insulin-
stimulated glucose uptake. Phosphatidylinositol 3-kinase (PI3K)-dependent insulin signaling …

Diabetes is a chronic and complex multifactorial disease caused by persistent
hyperglycemia and for which underlying pathogenesis is still not completely understood …

We present a biochemical model of the wall shear stress-induced activation of endothelial
nitric oxide synthase (eNOS) in an endothelial cell. The model includes three key …