Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …

The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer's
disease and the APOE ε2 allele the strongest genetic protective factor after multiple large …

For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …

Summary Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids,
predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to …

Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …

Neurodegenerative diseases are, according to recent studies, one of the main causes of
disability and death worldwide. Interest in molecular genetics has started to experience …

The importance of apolipoprotein E (APOE) in late-onset Alzheimer's disease (LOAD) has
been firmly established, but the mechanisms through which it exerts its pathogenic effects …

Although the biochemical and pathological hallmarks of Alzheimer's disease (AD), such as
axonal transport defects, synaptic loss, and selective neuronal death, are well characterized …

Age-related macular degeneration (AMD) damages the retinal pigment epithelium (RPE),
the tissue that safeguards photoreceptor health, leading to irreversible vision loss …