The contribution of glutamate to synaptic transmission, plasticity and development is well
established; current evidence is based on diverse approaches to decipher function and …

N-methyl-d-aspartate receptors (NMDARs) act as molecular coincidence detectors and
allow for association or dissociation between pre-and postsynaptic neurons. NMDA …

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …

N-Methyl-D-aspartate receptors (NMDARs) mediate certain forms of synaptic plasticity and
learning. We used a touchscreen system to assess NR2A subunit knockout mice (KO) for (1) …

The primary motor cortex has an important role in the precise execution of learned motor
responses. During motor learning, synaptic efficacy between sensory and primary motor …

N-methyl-D-aspartate (NMDA) receptors are present in high density within the cerebral
cortex and hippocampus and play an important role in learning and memory. NMDA …

The goal of this study was to determine whether trace eyeblink conditioning is a
hippocampally dependent associative learning task in the mouse. First, we examined trace …

Two genome duplications early in the vertebrate lineage expanded gene families, including
GluN2 subunits of the NMDA receptor. Diversification between the four mammalian GluN2 …

General or brain-region-specific decreases in spine number or morphology accompany
major neuropsychiatric disorders. It is unclear, however, whether changes in spine density …

In Pavlovian delay eyeblink conditioning, the cerebellum represents the passage‐of‐time
(POT) between onsets of conditioned and unconditioned stimuli (CS and US, respectively) …