Extracellular vesicles in kidney disease

C Grange, B Bussolati - Nature Reviews Nephrology, 2022 - nature.com
Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

A Ståhl, K Johansson, M Mossberg, R Kahn… - Pediatric …, 2019 - Springer
Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in
size, including exosomes, microvesicles, and apoptotic bodies. They are released under …

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

U Erdbrügger, CJ Blijdorp, IV Bijnsdorp… - Journal of …, 2021 - Wiley Online Library
Urine is commonly used for clinical diagnosis and biomedical research. The discovery of
extracellular vesicles (EV) in urine opened a new fast‐growing scientific field. In the last …

Extracellular vesicles in obesity and diabetes mellitus

F Pardo, R Villalobos-Labra, B Sobrevia… - Molecular aspects of …, 2018 - Elsevier
Cell-to-cell communication happens via diverse mechanisms including the synthesis,
release and transfer to target cells of extracellular vesicles (EVs). EVs include nanovesicles …

Extracellular vesicles in diagnosis and therapy of kidney diseases

W Zhang, X Zhou, H Zhang, Q Yao… - American Journal of …, 2016 - journals.physiology.org
Extracellular vesicles (EV) are endogenously produced, membrane-bound vesicles that
contain various molecules. Depending on their size and origins, EVs are classified into …

Urine exosomes: an emerging trove of biomarkers

JM Street, EH Koritzinsky, DM Glispie, RA Star… - Advances in clinical …, 2017 - Elsevier
Exosomes are released by most cells and can be isolated from all biofluids including urine.
Exosomes are small vesicles formed as part of the endosomal pathway that contain cellular …

Extracellular vesicles in renal diseases: more than novel biomarkers?

U Erdbrügger, TH Le - Journal of the American Society of …, 2016 - journals.lww.com
Extracellular vesicles from the urine and circulation have gained significant interest as
potential diagnostic biomarkers in renal diseases. Urinary extracellular vesicles contain …

Diabetic nephropathy: perspective on extracellular vesicles

Y Lu, D Liu, Q Feng, Z Liu - Frontiers in Immunology, 2020 - frontiersin.org
Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus. It is
the most frequent cause of end-stage renal disease with no definitive therapy available so …

Urinary extracellular vesicles and the kidney: biomarkers and beyond

M Salih, R Zietse, EJ Hoorn - American Journal of …, 2014 - journals.physiology.org
Extracellular vesicles have been isolated in various body fluids, including urine. The cargo
of urinary extracellular vesicles (uEVs) is composed of proteins and nucleic acids reflecting …

Extracellular vesicles in liquid biopsies: potential for disease diagnosis

J Liu, Y Chen, F Pei, C Zeng, Y Yao… - BioMed Research …, 2021 - Wiley Online Library
Liquid biopsy is conducted through minimally invasive or noninvasive procedures, and the
resulting material can be subjected to genomic, proteomic, and lipidomic analyses for early …