Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …

The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to
prominence in recent years. Understanding the relationship between the gut microbiota, the …

The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

Epidemiological studies have suggested a role for ultra-processed foods in numerous
chronic inflammatory diseases such as inflammatory bowel diseases and metabolic …

The gastrointestinal tract is continuously exposed to trillions of commensal microbes,
collectively termed the microbiota, which are environmental stimuli that can direct health and …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

The consumption of Western-type calorically rich diets combined with chronic overnutrition
and a sedentary lifestyle in Western societies evokes a state of chronic metabolic …

Short-chain fatty acids (SCFAs), the main metabolites produced by bacterial fermentation of
dietary fibre in the gastrointestinal tract, are speculated to have a key role in microbiota–gut …

Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet,
have been linked to beneficial effects on human health associated with their metabolic and …

There is increasing evidence showing that the dynamic changes in the gut microbiota can
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …