Background: There is no doubt that acute calcineurin inhibitor (CNI) nephrotoxicity exists;
however, chronic CNI nephrotoxicity is questionable at best. Methods: We reviewed the …

The paradigm that chronic rejection causes all progressive late allograft failure has been
replaced by a hypothesis of cumulative damage, where a series of time-dependent immune …

We studied the phenotype of late kidney graft failure in a prospective study of unselected
kidney transplant biopsies taken for clinical indications. We analyzed histopathology, HLA …

The 8th Banff Conference on Allograft Pathology was held in Edmonton, Canada, 15–21
July 2005. Major outcomes included the elimination of the non-specific term 'chronic allograft …

We studied whether de novo donor-specific antibodies (DSA) in sera from patients
undergoing kidney transplant biopsies associate with specific histologic lesions in the …

Endothelial deposition of the complement split product C4d is an established marker of
antibody-mediated acute renal allograft rejection. A contribution of alloantibody-dependent …

To define the relative frequency of phenotypes of transplant glomerulopathy, we
retrospectively reviewed the findings in 1036 biopsies for clinical indications from 1320 renal …

It is hypothesized that rarefaction of peritubular capillaries represents a critical event,
following ischemic injury, that permanently alters renal function and predisposes patients to …

Chronic allograft nephropathy (CAN) is the principal cause of late renal allograft failure. This
complex process is multifactorial in origin, and there is good evidence for immune-mediated …

As the histology is variable, the current diagnosis of humoral rejection in biopsies relies on
the demonstration of C4d, a component of the classical complement pathway, in peritubular …