Abstract Machine learning and artificial intelligence (AI/ML) models in healthcare may
exacerbate health biases. Regulatory oversight is critical in evaluating the safety and …

Summary The International Council for Harmonisation of Technical Requirements for
Pharmaceuticals for Human Use (ICH) E7, the guidance for the conduct of clinical trials in …

Background: Growing clinical interest in psychedelic-assisted therapies has led to a second
wave of research involving psilocybin, lysergic acid diethylamide (LSD), 3, 4 …

Abemaciclib demonstrated clinical benefit in women affected by HR+/HER2− advanced
breast cancer (aBC). Drug-drug interactions (DDIs) can lead to reduced treatment efficacy or …

Aims In many countries, pain is the most common indication for use of antidepressants in
older adults. We reviewed the evidence from randomized controlled trials on the efficacy and …

About one third of patients with Non-Small Cell Lung Cancer (NSCLC) present at diagnosis
with localized or locally advanced disease amenable to curative surgical resection. Surgical …

Most people with atrial fibrillation are older adults, in whom atrial fibrillation co-occurs with
other chronic conditions, polypharmacy, and geriatric syndromes such as frailty. Yet most …

The aim of this study was to investigate whether interventions to discontinue or down‐titrate
heart failure (HF) pharmacotherapy are feasible and associated with risks in older people. A …

Communication in oncology has always been challenging. The new era of precision
oncology creates prognostic uncertainty. Still, person-centered care requires attention to …

Objectives Osimertinib is the primary treatment for patients with epidermal growth factor
receptor (EGFR) mutation-positive advanced non-small cell lung cancer. However, evidence …