Lysyl oxidases: from enzyme activity to extracellular matrix cross-links
SD Vallet, S Ricard-Blum - Essays in biochemistry, 2019 - portlandpress.com
The lysyl oxidase family comprises five members in mammals, lysyl oxidase (LOX) and four
lysyl oxidase like proteins (LOXL1-4). They are copper amine oxidases with a highly …
lysyl oxidase like proteins (LOXL1-4). They are copper amine oxidases with a highly …
Lysyl oxidase like‐2 (LOXL2): an emerging oncology target
V Chopra, RM Sangarappillai… - Advanced …, 2020 - Wiley Online Library
Abstract Lysyl oxidase‐like 2 (LOXL2) is an emerging drug target against metastatic disease
owing to its role in the upregulation of key processes including epithelial‐mesenchymal …
owing to its role in the upregulation of key processes including epithelial‐mesenchymal …
[HTML][HTML] In silico analysis and molecular docking studies of potential angiotensin-converting enzyme inhibitor using quercetin glycosides
SA Muhammad, N Fatima - Pharmacognosy magazine, 2015 - ncbi.nlm.nih.gov
The purpose of this study was to analyze the inhibitory action of quercetin glycosides by
computational docking studies. For this, natural metabolite quercetin glycosides isolated …
computational docking studies. For this, natural metabolite quercetin glycosides isolated …
Flavone-based hydrazones as new tyrosinase inhibitors: Synthetic imines with emerging biological potential, SAR, molecular docking and drug-likeness studies
Targeting tyrosinase (TYR), a key enzyme responsible for melanogenesis disorders, is a
well-known approach utilized for the development of melanogenesis inhibitor. A variety of …
well-known approach utilized for the development of melanogenesis inhibitor. A variety of …
Design and synthesis of new flavonols as dual ɑ-amylase and ɑ-glucosidase inhibitors: structure-activity relationship, drug-likeness, in vitro and in silico studies
In this study, a library of new intriguing flavonol derivatives (1–17) was designed and
synthesized through a facile route involving Algar-Flynn-Oyamada reaction in a one-pot …
synthesized through a facile route involving Algar-Flynn-Oyamada reaction in a one-pot …
Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited
Lysyl oxidase (LOX) enzymes as potential drug targets maintain constant attention in the
therapy of fibrosis, cancer and metastasis. In order to measure the inhibitory activity of small …
therapy of fibrosis, cancer and metastasis. In order to measure the inhibitory activity of small …
Structure-based designing and synthesis of 2-phenylchromone derivatives as potent tyrosinase inhibitors: In vitro and in silico studies
J Ashraf, EU Mughal, RI Alsantali, RJ Obaid… - Bioorganic & Medicinal …, 2021 - Elsevier
The present study describes the discovery of novel inhibitors of mushroom tyrosinase
enzyme. For that purpose, a series of varyingly substituted 2-phenylchromone analogues 1 …
enzyme. For that purpose, a series of varyingly substituted 2-phenylchromone analogues 1 …
Cytotoxic Evaluation, Molecular Docking, and 2D‐QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents
The diverse pharmacological role of dihydropyrimidinone scaffold has made it to be an
interesting drug target. Because of the high incidence and mortality rate of breast cancer …
interesting drug target. Because of the high incidence and mortality rate of breast cancer …
Anti-proliferative and computational studies of two new pregnane glycosides from Desmidorchis flava
MA Raees, H Hussain, A Al-Rawahi, R Csuk… - Bioorganic …, 2016 - Elsevier
Two new pregnane glycosides named desmiflavasides C (1) and D (2) were isolated from
the sap of Desmidorchis flava (NE Br.) Meve & Liede and have had their structures …
the sap of Desmidorchis flava (NE Br.) Meve & Liede and have had their structures …
Computational drug designing of fungal pigments as potential aromatase inhibitors
The existing aromatase inhibitors produced unwelcome effects impose the discovery of
novel drugs with privileged selectivity, a reduced amount of toxicity and humanizing potency …
novel drugs with privileged selectivity, a reduced amount of toxicity and humanizing potency …