Mechanisms underlying sex differences in autoimmunity

DL Fairweather, DJ Beetler, EJ McCabe… - The Journal of clinical …, 2024 - jci.org
Autoimmune diseases are a leading cause of disability worldwide. Most autoimmune
diseases occur more often in women than men, with rheumatic autoimmune diseases being …

The role of gonadal hormones and sex chromosomes in sex-dependent effects of early nutrition on metabolic health

JK Christians, K Reue - Frontiers in Endocrinology, 2023 - frontiersin.org
Early-life conditions such as prenatal nutrition can have long-term effects on metabolic
health, and these effects may differ between males and females. Understanding the …

Glia dysfunction in schizophrenia: evidence of possible therapeutic effects of nervonic acid in a preclinical model

X Wang, J Fu, H Wang, C Liu, Y Zhang, C Song… - …, 2024 - Springer
Rationale Neuroinflammation may inhibit oligodendrocyte and astrocyte differentiation,
which causes demyelination and synaptic degeneration. The myelin component nervonic …

Paternal hypercholesterolemia elicits sex-specific exacerbation of atherosclerosis in offspring

R Hernandez, X Li, J Shi, TR Dave, T Zhou… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Emerging studies suggest that various parental exposures affect offspring cardiovascular
health, yet the specific mechanisms, particularly the influence of paternal cardiovascular …

The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation

CB Wiese, B Soliman, K Reue - Biology of sex Differences, 2024 - Springer
Abstract The Four Core Genotypes (FCG) mouse model has become a valuable model to
study the mechanistic basis for biological sex differences. This model allows discrimination …

[HTML][HTML] Régulation du chromosome X et spécificités fonctionnelles des cellules femelles-Deux X valent-ils mieux qu'un?

J Chaumeil, C Morey - médecine/sciences, 2024 - medecinesciences.org
Et si posséder deux chromosomes X conférait aux cellules femelles des spécificités
exclusives et expliquait les différences de susceptibilité des hommes et des femmes à …

Gene regulation and mitochondrial activity during white and brown adipogenesis are modulated by KDM5 histone demethylase

L Vergnes, CB Wiese, T Zore… - Journal of the …, 2024 - academic.oup.com
Body fat accumulation differs between males and females and is influenced by both gonadal
sex (ovaries vs testes) and chromosomal sex (XX vs XY). We previously showed that an X …

Characterising the Sexual Dimorphisms of the Vasculature in Metabolic Syndrome

V Tran - 2024 - opal.latrobe.edu.au
Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the
Centre for Cardiovascular Biology and Disease Research, La Trobe Institute for Molecular …

[HTML][HTML] Chronic Conditions That Predominantly Impact or Affect Women Differently

Z Batulan, A Bhimla, EJ Higginbotham… - … Research on Chronic …, 2024 - ncbi.nlm.nih.gov
This chapter describes the research progress on and advances in understanding chronic
conditions present in both women and men that predominantly impact or affect women …

Novel Insights Into the Mechanisms of Atherosclerosis

R Hernandez - 2024 - search.proquest.com
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of
lipids, immune cells, necrotic cells, and other fibrous material in the subintimal space of …