Signaling by the tumor necrosis factor receptor superfamily in B‐cell biology and disease

RC Rickert, J Jellusova, AV Miletic - Immunological reviews, 2011 - Wiley Online Library
Members of the tumor necrosis factor receptor superfamily (TNFRSF) participate prominently
in B‐cell maturation and function. In particular, B‐cell activating factor belonging to the TNF …

B-cell maturation antigen expression across hematologic cancers: a systematic literature review

A Dogan, D Siegel, N Tran, A Fu, J Fowler… - Blood cancer …, 2020 - nature.com
B-cell maturation antigen (BCMA) plays a critical role in regulating B-cell proliferation and
survival. There is evidence for BCMA expression in various hematologic malignancies …

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

YT Tai, C Acharya, G An, M Moschetta… - Blood, The Journal …, 2016 - ashpublications.org
Here we show that overexpression or activation of B-cell maturation antigen (BCMA) by its
ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) …

Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma

YT Tai, PA Mayes, C Acharya, MY Zhong… - Blood, The Journal …, 2014 - ashpublications.org
B-cell maturation antigen (BCMA), highly expressed on malignant plasma cells in human
multiple myeloma (MM), has not been effectively targeted with therapeutic monoclonal …

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

S Hipp, YT Tai, D Blanset, P Deegen, J Wahl… - Leukemia, 2017 - nature.com
B-cell maturation antigen (BCMA) is a highly plasma cell-selective protein that is expressed
on malignant plasma cells of multiple myeloma (MM) patients and therefore is an ideal target …

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications

YT Tai, Y Landesman, C Acharya, Y Calle, MY Zhong… - Leukemia, 2014 - nature.com
The key nuclear export protein CRM1/XPO1 may represent a promising novel therapeutic
target in human multiple myeloma (MM). Here we showed that chromosome region …

Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through …

W Li, B Zhang, W Cao, W Zhang, T Li, L Liu… - … Hematology & Oncology, 2023 - Springer
Abstract Background BCMA CAR-T is highly effective for relapsed/refractory multiple
myeloma (R/R-MM) and significantly improves the survival of patients. However, the short …

An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma

L Lee, B Draper, N Chaplin, B Philip… - Blood, The Journal …, 2018 - ashpublications.org
B-cell maturation antigen (BCMA) is a promising therapeutic target for multiple myeloma
(MM), but expression is variable, and early reports of BCMA targeting chimeric antigen …

Evaluation of B cell maturation antigen as a target for antibody drug conjugate mediated cytotoxicity in multiple myeloma

L Lee, D Bounds, J Paterson… - British journal of …, 2016 - Wiley Online Library
B‐cell maturation antigen (BCMA, also termed TNFRSF 17) is an attractive therapeutic target
due to its restricted expression on normal and malignant plasma cells (PC). GSK 2857916 …

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

YT Tai, BY Chang, SY Kong, M Fulciniti… - Blood, The Journal …, 2012 - ashpublications.org
Bruton tyrosine kinase (Btk) has a well-defined role in B-cell development, whereas its
expression in osteoclasts (OCs) further suggests a role in osteoclastogenesis. Here we …