Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Lumbar disc degeneration is one of the leading causes of chronic low back pain. The
degenerative cascade is often initiated by an imbalance between catabolic and anabolic …

Intervertebral disc degeneration is highly prevalent within the elderly population and is a
leading cause of chronic back pain and disability. Due to the link between disc degeneration …

Iron overload is a common phenomenon in the elderly population. Many clinical studies
have indicated an association between iron overload and the incidence and pathological …

Low back pain (LBP) is a common disease that imposes a huge social and economic
burden on people. Intervertebral disc (IVD) degeneration (IVDD) is often considered to be …

Intervertebral disc degeneration is a very common type of degenerative disease causing
severe socioeconomic impact, as well as a major cause of discogenic low back pain and …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

With an aging population, there is a proportional increase in the prevalence of intervertebral
disc diseases. Intervertebral disc diseases are the leading cause of lower back pain and …

Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic
and catabolic processes in the intervertebral disc, leading to an alteration in the composition …

Intervertebral disc (IVD) degeneration is a multifactorial pathological process associated
with low back pain, the leading cause of years lived in disability worldwide. Key …