Calcium transport proteins in fungi: the phylogenetic diversity of their relevance for growth, virulence, and stress resistance

M Lange, E Peiter - Frontiers in microbiology, 2020 - frontiersin.org
The key players of calcium (Ca2+) homeostasis and Ca2+ signal generation, which are
Ca2+ channels, Ca2+/H+ antiporters, and Ca2+-ATPases, are present in all fungi. Their …

Calcium signaling pathway is involved in non-CYP51 azole resistance in Aspergillus fumigatus

Y Li, Y Zhang, L Lu - Medical mycology, 2019 - academic.oup.com
The opportunistic fungal pathogen Aspergillus fumigatus, which is one of the primary
airborne ascomycete pathogens and allergens worldwide, causes invasive fungal infections …

Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses

CH Yu, Y Chen, CA Desjardins, JL Tenor… - Microbial …, 2020 - microbiologyresearch.org
Cryptococcus neoformans is an opportunistic fungal pathogen that at its peak epidemic
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …

Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans

C Fu, N Donadio, ME Cardenas, J Heitman - Genetics, 2018 - academic.oup.com
Abstract The Ca2+/calmodulin-dependent protein phosphatase calcineurin orchestrates
sexual reproduction, stress responses, and virulence via branched downstream pathways in …

The transcription factor Pdr802 regulates titan cell formation and pathogenicity of Cryptococcus neoformans

JCV Reuwsaat, DP Agustinho, H Motta, AL Chang… - Mbio, 2021 - Am Soc Microbiol
Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills almost
200,000 people worldwide each year. It is acquired when mammalian hosts inhale the …

Insights into the Multi-Azole Resistance Profile in Candida haemulonii Species Complex

LN Silva, LS Ramos, SSC Oliveira, LB Magalhães… - Journal of Fungi, 2020 - mdpi.com
The Candida haemulonii complex (C. duobushaemulonii, C. haemulonii, and C. haemulonii
var. vulnera) is composed of emerging, opportunistic human fungal pathogens able to cause …

Cryptococcus neoformans–astrocyte interactions: effect on fungal blood brain barrier disruption, brain invasion, and meningitis progression

YH Woo, LR Martinez - Critical reviews in microbiology, 2021 - Taylor & Francis
Cryptococcus neoformans is an opportunistic, neurotropic, and encapsulated fungus that
causes life-threatening cryptococcal meningitis (CM), especially in regions of the world …

Participation of Zip3, a ZIP domain-containing protein, in stress response and virulence in Cryptococcus gattii

AWA Garcia, UP Kinskovski, C Diehl… - Fungal Genetics and …, 2020 - Elsevier
Cryptococcus gattii is an etiologic agent of cryptococcosis, a potentially fatal disease that
affects humans and animals. The successful infection of mammalian hosts by cryptococcal …

Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans

RT Menezes, TC Pereira, JC Junqueira… - Anais da Academia …, 2022 - SciELO Brasil
This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus
neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal …

[HTML][HTML] The V-ATPase regulates localization of the TRP Ca2+ channel Yvc1 in response to oxidative stress in Candida albicans

L Peng, Q Yu, H Zhu, N Zhu, B Zhang, H Wei… - International Journal of …, 2020 - Elsevier
The vacuolar-type H+-ATPase (V-ATPase) is a highly conserved protein complex among the
eukaryotic cells. We previously revealed that both the V-ATPase and the transient receptor …