Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last
decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

The discovery of steroid hormone receptors in brain regions that mediate every aspect of
brain function has broadened the definition of 'neuroendocrinology'to include the reciprocal …

Background Community-acquired pneumonia (CAP) is a leading cause of morbidity and
mortality. Corticosteroids may be a beneficial adjunct in the treatment of bacterial …

Pulmonary arterial hypertension (PAH) is a chronic pulmonary vascular disease
characterized by increased pulmonary vascular resistance (PVR) leading to right ventricular …

Fibrosis and remodeling of the right ventricle (RV) are associated with RV dysfunction and
mortality of patients with pulmonary hypertension (PH) but it is unknown how much RV …

Germline mutations involving small mothers against decapentaplegic–transforming growth
factor–β (SMAD–TGF-β) signaling are an important but rare cause of pulmonary arterial …

Aldosterone controls salt–water homeostasis by acting on the mineralocorticoid receptor
(MR), a ligand-activated transcription factor, in kidney epithelial cells. However, it is now …

Right‐sided heart failure and tricuspid regurgitation are common and strongly associated
with poor quality of life and an increased risk of heart failure hospitalizations and death …