Mechanisms and treatment of late-life depression

GS Alexopoulos - Translational psychiatry, 2019 - nature.com
Depression predisposes to medical illnesses and advances biological aging indicated by
shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical …

Psychobiological factors of resilience and depression in late life

KT Laird, B Krause, C Funes, H Lavretsky - Translational psychiatry, 2019 - nature.com
In contrast to traditional perspectives of resilience as a stable, trait-like characteristic,
resilience is now recognized as a multidimentional, dynamic capacity influenced by life-long …

The vascular depression hypothesis: mechanisms linking vascular disease with depression

WD Taylor, HJ Aizenstein, GS Alexopoulos - Molecular psychiatry, 2013 - nature.com
Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

Frontocingulate dysfunction in depression: toward biomarkers of treatment response

DA Pizzagalli - Neuropsychopharmacology, 2011 - nature.com
Increased rostral anterior cingulate cortex (rACC) activity has emerged as a promising
predictor of treatment response in depression, but neither the reliability of this relationship …

The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features

SL Naismith, LM Norrie, L Mowszowski… - Progress in neurobiology, 2012 - Elsevier
As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

A systematic review of executive function and information processing speed in major depression disorder

L Nuño, J Gómez-Benito, VR Carmona, O Pino - Brain Sciences, 2021 - mdpi.com
Background: Major depression is a psychiatric disorder characterized neuropsychologically
by poor performance in tasks of memory, attention, processing speed, and executive …

Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction

PA Areán, P Raue, RS Mackin… - American journal of …, 2010 - Am Psychiatric Assoc
Objective: The purpose of this study was to determine whether problem-solving therapy is an
effective treatment in older patients with depression and executive dysfunction, a population …

Diagnosis and treatment of depression and cognitive impairment in late life

SS Morimoto, D Kanellopoulos… - Annals of the New …, 2015 - Wiley Online Library
Cognitive impairment in late‐life depression is prevalent, disabling, and heterogeneous.
Although mild cognitive impairment in depression does not usually progress to dementia …

Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability

GS Alexopoulos, PJ Raue, DN Kiosses… - Archives of general …, 2011 - jamanetwork.com
Context Older patients with depression and executive dysfunction represent a population
with significant disability and a high likelihood of failing pharmacotherapy. Objectives To …

[HTML][HTML] Dysregulation of inflammation, neurobiology, and cognitive function in PTSD: an integrative review

MM Quinones, AM Gallegos, FV Lin… - Cognitive, Affective, & …, 2020 - Springer
Compelling evidence from animal and human research suggest a strong link between
inflammation and posttraumatic stress disorder (PTSD). Furthermore, recent findings support …