The potential and challenges of nanopore sequencing

D Branton, DW Deamer, A Marziali, H Bayley… - Nature …, 2008 - nature.com
A nanopore-based device provides single-molecule detection and analytical capabilities
that are achieved by electrophoretically driving molecules in solution through a nano-scale …

The evolution of nanopore sequencing

Y Wang, Q Yang, Z Wang - Frontiers in genetics, 2015 - frontiersin.org
The “1000Genome”projecthasbeendrawingincreasingattention….Nanoporesequencing,
thethird-generation,isbelievedtobeoneofthemostpromisingsequ…“ 1000 Genome” while the …

Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore

D Stoddart, AJ Heron, E Mikhailova… - Proceedings of the …, 2009 - National Acad Sciences
The sequencing of individual DNA strands with nanopores is under investigation as a rapid,
low-cost platform in which bases are identified in order as the DNA strand is transported …

Colloquium: Physical approaches to DNA sequencing and detection

M Zwolak, M Di Ventra - Reviews of Modern Physics, 2008 - APS
With the continued improvement of sequencing technologies, the prospect of genome-based
medicine is now at the forefront of scientific research. To realize this potential, however, a …

[PDF][PDF] Tip‐enhanced Raman spectroscopy of single RNA strands: towards a novel direct‐sequencing method

E Bailo, V Deckert - Angewandte Chemie International Edition, 2008 - academia.edu
The sequencing of DNA or proteins is procedurally complex and requires sophisticated
analytical techniques.[1, 2] DNA sequencing while a very powerful method requires …

Electronic signatures of all four DNA nucleosides in a tunneling gap

S Chang, S Huang, J He, F Liang, P Zhang, S Li… - Nano …, 2010 - ACS Publications
Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of
sub-millisecond duration with a broad distribution of peak currents. This distribution narrows …

Partial sequencing of a single DNA molecule with a scanning tunnelling microscope

H Tanaka, T Kawai - Nature nanotechnology, 2009 - nature.com
The scanning tunnelling microscope is capable of the real-space imaging and spectroscopy
of molecules on an atomic scale. Numerous attempts have been made to use the scanning …

Perspectives and challenges of emerging single‐molecule DNA sequencing technologies

M Xu, D Fujita, N Hanagata - Small, 2009 - Wiley Online Library
The growing demand for analysis of the genomes of many species and cancers, for
understanding the role of genetic variation among individuals in disease, and with the …

Controlled translocation of individual DNA molecules through protein nanopores with engineered molecular brakes

M Rincon-Restrepo, E Mikhailova, H Bayley… - Nano …, 2011 - ACS Publications
Protein nanopores may provide a cheap and fast technology to sequence individual DNA
molecules. However, the electrophoretic translocation of ssDNA molecules through protein …

Tunnelling readout of hydrogen-bonding-based recognition

S Chang, J He, A Kibel, M Lee, O Sankey… - Nature …, 2009 - nature.com
Hydrogen bonding has a ubiquitous role in electron transport, and in molecular recognition,
with DNA base pairing being the best-known example. Scanning tunnelling microscope …