MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of
gene regulation that coordinates a broad spectrum of biological processes. Bone …

Background Articular cartilage defects are a veritable therapeutic problem because
therapeutic options are very scarce. Due to the poor self-regeneration capacity of cartilage …

Chondrocytes and osteoblasts are two primary cell types in the skeletal system that are
differentiated from common mesenchymal progenitors. It is believed that osteoblast …

Both activating and null mutations of proteins required for canonical WNT signaling have
revealed the importance of this pathway for normal skeletal development. However, tissue …

We present an overview of the concepts of tissue-specific transcriptional control
mechanisms essential for development of the bone cell phenotype. BMP2 induced …

Chondrocyte hypertrophy is one of the key physiological processes involved in the
longitudinal growth of long bones, yet regulation of hypertrophy is becoming increasingly …

There are increasing reports that mesenchymal stem cells (MSCs) are present in various
tissues other than bone marrow, including synovium. Here we investigated the optimal …

Due to a blood supply shortage, articular cartilage has a limited capacity for self-healing
once damaged. Articular chondrocytes, cartilage progenitor cells, embryonic stem cells, and …

We investigated the molecular mechanisms underlying canonical Wnt‐mediated regulation
of chondrocyte hypertrophy using chick upper sternal chondrocytes. Replication competent …

Drug targeting of adult stem cells has been proposed as a strategy for regenerative
medicine, but very few drugs are known to target stem cell populations in vivo. Mesenchymal …