Chronic psychosocial stress increases disease risk and mortality, but the underlying
mechanisms remain largely unclear. Here we outline an energy-based model for the …

Pathological deterioration of mitochondrial function is increasingly linked with multiple
degenerative illnesses as a mediator of a wide range of neurologic and age-related chronic …

Mitochondrial diseases (MDs) are a group of severe genetic disorders caused by mutations
in the nuclear or mitochondrial genome encoding proteins involved in the oxidative …

Triggering receptor expressed on myeloid cells 2 (Trem2) is a myeloid cell-specific gene
expressed in brain microglia, with variants that are associated with neurodegenerative …

C1q, the initiator of the classical pathway of the complement system, is activated during
Alzheimer's disease (AD) development and progression and is especially associated with …

Background Transplantation of stem cells for treating neurodegenerative disorders is a
promising future therapeutic approach. However, the molecular mechanism underlying the …

Over the years, the advancement of radio diagnostic imaging tools and techniques has
radically improved the diagnosis of different pathophysiological conditions, accompanied by …

Mitochondrial DNA (mtDNA) diseases are multi‐systemic disorders caused by mutations
affecting a fraction or the entirety of mtDNA copies. Currently, there are no approved …

Inflammatory bowel disease (IBD) is one of the leading gut chronic inflammation disorders,
especially prevalent in Western countries. Recent research suggests that mitochondria play …

Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with the
hallmark of abnormal aggregates of alpha-synuclein (α-syn) in Lewy bodies (LBs) and Lewy …