The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

Nuclear export is an essential eukaryotic activity. It proceeds through nuclear pore
complexes (NPCs) and is mediated by soluble receptors that shuttle between nucleus and …

Abstract The DExD/H-box ATPase Dbp5 is essential for nuclear mRNA export, although its
precise role in this process remains poorly understood. Here, we identify the nuclear pore …

CRM1 or XPO1 is the major nuclear export receptor in the cell, which controls the nuclear-
cytoplasmic localization of many proteins and RNAs. CRM1 is also a promising cancer drug …

Saccharomyces cerevisiae Pkh1 and Pkh2 are functionally redundant homologs of
mammalian protein kinase, phosphoinositide-dependent protein kinase-1. They activate two …

Accurate translation of the genetic code into functional polypeptides is key to cellular growth
and proliferation. This essential process is carried out by the ribosome, a ribonucleoprotein …

Continuous cycles of nucleocytoplasmic transport require disassembly of transport
receptor/Ran-GTP complexes in the cytoplasm. A basic disassembly mechanism in all …

Pab1 is the major poly (A)-binding protein in yeast. It is a multifunctional protein that
mediates many cellular functions associated with the 3′-poly (A)-tail of messenger RNAs …

Rrp12p (Ypl012w) is unusual among characterized ribosome synthesis factors in being
associated with late precursors to both the 40S and 60S subunits. Rrp12p is predominately …

The karyopherin CRM1 mediates nuclear export of proteins and ribonucleoproteins bearing
a leucine‐rich nuclear export signal (NES). To elucidate the precise mechanism by which …