In this review, we provide an organized summary of the theoretical and computational
results that are available for polymers subject to spatial or topological constraints. Because …

While the widespread emergence of nanoscience and nanotechnology can be dated back to
the early eighties, the last decade has witnessed a true coming of age of this research field …

In many cases, transcriptional regulation involves the binding of transcription factors at sites
on the DNA that are not immediately adjacent to the promoter of interest. This action at a …

At many promoters, transcription is regulated by simultaneous binding of a protein to
multiple sites on DNA, but the structures and dynamics of such transcription factor-mediated …

Horizontal DNA transfer plays a major role in the evolution of bacteria. It allows them to
acquire new traits rapidly and these may confer fitness advantages as the bacteria compete …

Supercoiling can alter the form and base pairing of the double helix and directly impact
protein binding. More indirectly, changes in protein binding and the stress of supercoiling …

The tethered particle motion (TPM) technique informs about conformational changes of DNA
molecules, eg upon looping or interaction with proteins, by tracking the Brownian motion of a …

Architectural DNA binding proteins are key to the organization and compaction of genomic
DNA inside cells. Tethered Particle Motion (TPM) permits analysis of DNA conformation and …

Abstract The Tethered Particle Motion (TPM) method has been used to observe and
characterize a variety of protein-DNA interactions including DNA loping and transcription …

As the chief informational molecule of life, DNA is subject to extensive physical
manipulations. The energy required to deform double-helical DNA depends on sequence …