Cell-permeable peptide-based delivery vehicles useful for subcellular targeting and beyond

K Stillger, I Neundorf - Cellular Signalling, 2023 - Elsevier
Personal medicine aims to provide tailor-made diagnostics and treatments and has been
emerged as a promising but challenging strategy during the last years. This includes the …

Analysis of spike protein variants evolved in a novel in vivo long-term replication model for SARS-CoV-2

D Kim, J Kim, M Kim, H Park, S Park… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction The spectrum of SARS-CoV-2 mutations have increased over time, resulting in
the emergence of several variants of concern. Persistent infection is assumed to be involved …

Cell-Penetrating Peptides in infection and immunization

Y Du, Y Xiong, Z Sha, D Guo, B Fu, X Lin, H Wu - Microbiological Research, 2024 - Elsevier
Bacteria and viruses pose significant threats to human health, as drug molecules and
therapeutic agents are often hindered by cell membranes and tissue barriers from reaching …

Complementary Pocket and Network-Based Approach to Search for Spike Protein Allosteric Pocket Sites

RL Cheng, JC Quirante, LEZ Vargas, AF Gatchalian… - ACS …, 2023 - ACS Publications
COVID-19 is a persistent public health concern due to the emergence of more virulent and
contagious variants resulting from mutations in the spike protein. The spike protein in newer …

Unraveling stereochemical structure-activity relationships of sesquiterpene lactones for inhibitory effects on STAT3 activation

S An, J Chun, J Lee, YS Kim, M Noh… - Biomolecules & …, 2024 - pmc.ncbi.nlm.nih.gov
Sesquiterpene lactones, a class of natural compounds abundant in the Asteraceae family,
have gained attention owing to their diverse biological activities, and particularly their anti …

A mouse xenograft long‐term replication yields a SARS‐CoV‐2 Delta mutant with increased lethality

D Kim, M Kim, J Kim, K Baek, H Park… - Journal of Medical …, 2024 - Wiley Online Library
We recently established a long‐term SARS‐CoV‐2 infection model using lung‐cancer
xenograft mice and identified mutations that arose in the SARS‐CoV‐2 genome during long …

Production of a monoclonal antibody targeting the SARS-CoV-2 Omicron spike protein and analysis of SARS-CoV-2 Omicron mutations related to monoclonal …

J Kim, S Kim, S Park, D Kim, M Kim, K Baek… - Microbes and …, 2024 - Elsevier
SARS-CoV-2 mutations have resulted in the emergence of multiple concerning variants, with
Omicron being the dominant strain presently. Therefore, we developed a monoclonal …

Recent advances in the exploration and discovery of SARS-CoV-2 inhibitory peptides from edible animal proteins

X Kong, W Wang, Y Zhong, N Wang, K Bai, Y Wu… - Frontiers in …, 2024 - frontiersin.org
The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which causes the
coronavirus disease 2019 (COVID-19), is spreading worldwide. Although the COVID-19 …

[PDF][PDF] Analysis of SARS-CoV-2 Mutations after Nirmatrelvir Treatment in a Lung Cancer Xenograft Mouse Model

BM Kang, D Kim, J Kim, K Baek, S Park… - Biomolecules & …, 2024 - biomolther.org
Paxlovid is the first approved oral treatment for coronavirus disease 2019 and includes
nirmatrelvir, a protease inhibitor targeting the main protease (Mpro) of SARS-CoV-2, as one …

Targeting Specific Barriers

Ü Langel - CPP, Cell-Penetrating Peptides, 2023 - Springer
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