Neuronal circuitry for recognition memory of object and place in rodent models
Rats and mice are used for studying neuronal circuits underlying recognition memory due to
their ability to spontaneously remember the occurrence of an object, its place and an …
their ability to spontaneously remember the occurrence of an object, its place and an …
Control of synaptic plasticity in deep cortical networks
PR Roelfsema, A Holtmaat - Nature Reviews Neuroscience, 2018 - nature.com
Humans and many other animals have an enormous capacity to learn about sensory stimuli
and to master new skills. However, many of the mechanisms that enable us to learn remain …
and to master new skills. However, many of the mechanisms that enable us to learn remain …
Long-term depression in the CNS
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a
process that may be involved in learning and memory and in various pathological …
process that may be involved in learning and memory and in various pathological …
The physics of optimal decision making: a formal analysis of models of performance in two-alternative forced-choice tasks.
In this article, the authors consider optimal decision making in two-alternative forced-choice
(TAFC) tasks. They begin by analyzing 6 models of TAFC decision making and show that all …
(TAFC) tasks. They begin by analyzing 6 models of TAFC decision making and show that all …
Modes and models of forebrain cholinergic neuromodulation of cognition
ME Hasselmo, M Sarter - Neuropsychopharmacology, 2011 - nature.com
As indicated by the profound cognitive impairments caused by cholinergic receptor
antagonists, cholinergic neurotransmission has a vital role in cognitive function, specifically …
antagonists, cholinergic neurotransmission has a vital role in cognitive function, specifically …
The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies
I Klinkenberg, A Blokland - Neuroscience & Biobehavioral Reviews, 2010 - Elsevier
Scopolamine is used as a standard/reference drug for inducing cognitive deficits in healthy
humans and animals. Effects are often interpreted in terms of a role of acetylcholine in …
humans and animals. Effects are often interpreted in terms of a role of acetylcholine in …
Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease
C Lüscher, KM Huber - Neuron, 2010 - cell.com
Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate
receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 …
receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 …
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
Rats and mice are attracted by novel objects. They readily approach novel objects and
explore them with their vibrissae, nose and forepaws. It is assumed that such a single …
explore them with their vibrissae, nose and forepaws. It is assumed that such a single …
Object recognition memory: neurobiological mechanisms of encoding, consolidation and retrieval
Tests of object recognition memory, or the judgment of the prior occurrence of an object,
have made substantial contributions to our understanding of the nature and neurobiological …
have made substantial contributions to our understanding of the nature and neurobiological …
Acetylcholine and attention
I Klinkenberg, A Sambeth, A Blokland - Behavioural brain research, 2011 - Elsevier
Historically, ACh has been implicated in learning and short-term memory functions.
However, more recent studies have provided support for a role of cortical ACh in attentional …
However, more recent studies have provided support for a role of cortical ACh in attentional …