Recent years have seen an outpouring of atomic or near atomic resolution structures of
cyclic nucleotide-gated (CNG) channels, captured in closed, transition, pre-open, partially …

The function of proteins is linked to their conformations that can be resolved with several
high-resolution methods. However, only a few methods can provide the temporal order of …

The family of cystathionine-β-synthase (CBS)-pair domain divalent metal cation transport
mediators (CNNMs) is composed of four integral membrane proteins associated with Mg 2+ …

Cyclic nucleotide-modulated channels have important roles in visual signal transduction and
pacemaking. Binding of cyclic nucleotides (cAMP/cGMP) elicits diverse functional responses …

Statistically sound crystallographic symmetry classifications are obtained with information-
theory-based methods in the presence of approximately Gaussian distributed noise. A set of …

Cyclic nucleotide–modulated ion channels play several essential physiological roles. They
are involved in signal transduction in photoreceptors and olfactory sensory neurons as well …

Electron crystallography can reveal the structure of membrane proteins within 2D crystals
under close-to-native conditions. High-resolution structural information can only be reached …

SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta thermophila, activates
slowly upon cAMP increase. This is reminiscent of the slow, cAMP-induced activation …

Highlights•Electron crystallography from 2D-or thin 3D crystals may provide structural
information which is difficult to obtain with other methods.•3D maps are related to the …

The voltage-sensing domain (VSD) is a module capable of responding to changes in the
membrane potential through conformational changes and facilitating electromechanical …