Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix
as a response to different types of tissue injuries, which leads to organ dysfunction. The …

Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

COVID-19 is a disease caused by the coronavirus SARS-CoV-2 (Severe Acute Respiratory
Syndrome Coronavirus-2), known as a highly contagious disease, currently affecting more …

Abstract The coronavirus disease 2019 (COVID-19) outbreak is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 …

Rationale: Neurogenic hypertension is characterized by an increase in sympathetic activity
and often resistance to drug treatments. We previously reported that it is also associated with …

Significance: Cancer is a complex disease, which not only involves the tumor but its
microenvironment comprising different immune cells as well. Nitric oxide (NO) plays specific …

Aim The COVID-19 pandemic caused by infection with the novel coronavirus SARS-CoV-2
is urging the scientific community worldwide to intense efforts for identifying and developing …

Brain renin angiotensin system within the paraventricular nucleus plays a critical role in
balancing excitatory and inhibitory inputs to modulate sympathetic output and blood …

This clinical review paper discusses the pathophysiology of the pulmonary and
cardiovascular manifestations of a SARS-CoV-2 infection and the ensuing implications on …

The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-
converting enzyme 2), which acts as a double-edged sword, because ACE2 increases the …