Comprehensive and critical view on the anti-inflammatory and immunomodulatory role of natural phenolic antioxidants

AM Pisoschi, F Iordache, L Stanca, C Cimpeanu… - European Journal of …, 2024 - Elsevier
The immune response encompasses innate and adaptive immunity, each with distinct and
specific activities. The innate immune system is constituted by phagocytic cells …

Potential chemopreventive effects of dietary combination of phytochemicals against cancer development

T Tanaka, R Aoki, M Terasaki - Pharmaceuticals, 2023 - mdpi.com
Cancer remains a major cause of cancer-related death worldwide. Over 70% of epithelial
malignancies are sporadic and are related to lifestyle. Epidemiological studies suggest an …

Antioxidant potential of diosmin and diosmetin against oxidative stress in endothelial cells

M Wójciak, M Feldo, G Borowski, T Kubrak, BJ Płachno… - Molecules, 2022 - mdpi.com
Phlebotropic flavonoids, including diosmin and its aglycone diosmetin, are natural
polyphenols widely used in the prevention and treatment of chronic venous insufficiency …

Natural Deep Eutectic Solvent Optimization to Obtain an Extract Rich in Polyphenols from Capsicum chinense Leaves Using an Ultrasonic Probe

KA Avilés-Betanzos, JV Cauich-Rodríguez… - Processes, 2023 - mdpi.com
Capsicum chinense Jacq., from the Yucatan peninsula, is recognized worldwide for its
pungency, flavor, and secondary metabolites content. This has resulted in an increase in its …

Tailored biosynthesis of diosmin through reconstitution of the flavonoid pathway in Nicotiana benthamiana

H Lee, S Park, SB Lee, J Song, TH Kim… - Frontiers in Plant …, 2024 - frontiersin.org
The flavonoid diosmin (diosmetin 7-O-rutinoside) is used as a therapeutic agent for
disorders of the blood vessels such as hemorrhoids and varicose veins. Diosmin is …

Preparation and evaluation of diosmin-loaded diphenylcarbonate-cross-linked cyclodextrin nanosponges for breast cancer therapy

MK Anwer, MM Ahmed, MF Aldawsari, M Iqbal… - Pharmaceuticals, 2022 - mdpi.com
In the current study, diosmin (DSM)-loaded beta-cyclodextrin (β-CD)-based nanosponges
(NSPs) using diphenylcarbonate (DPC) as a cross-linker were prepared. Four different DSM …

Investigation of the efficacy of diosmin against organ damage caused by bendiocarb in male Wistar albino rats

O Bahar, G Eraslan - Environmental Science and Pollution Research, 2023 - Springer
Bendiocarb is a carbamate insecticide, which is used more in indoor areas, especially
against scorpions, spiders, flies, mosquitoes and cockroaches. Diosmin is an antioxidant …

An approach for systems-level understanding of prostate cancer from high-throughput data integration to pathway modeling and simulation

M Mobashir, SP Turunen, MA Izhari, IM Ashankyty… - Cells, 2022 - mdpi.com
To understand complex diseases, high-throughput data are generated at large and multiple
levels. However, extracting meaningful information from large datasets for comprehensive …

Factors influencing venous remodeling in the development of varicose veins of the lower limbs

L Gwozdzinski, A Pieniazek, K Gwozdzinski - International Journal of …, 2024 - mdpi.com
One of the early symptoms of chronic venous disease (CVD) is varicose veins (VV) of the
lower limbs. There are many etiological environmental factors influencing the development …

Identification of diosmin and flavin adenine dinucleotide as repurposing treatments for monkeypox virus: a computational study

TP Lam, VH Tran, TT Mai, NVT Lai, BTN Dang… - International Journal of …, 2022 - mdpi.com
The World Health Organization declared monkeypox a global public health emergency on
23 July 2022. This disease was caused by the monkeypox virus (MPXV), which was first …