Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high
morbidity and mortality rates. The development of novel therapies for sepsis is critically …

The immune response to acute cerebral ischemia is a major contributor to stroke
pathobiology. The inflammatory response is characterized by the participation of brain …

Several growth factors are expressed in distinct temporal and spatial patterns during fracture
repair. Of these, vascular endothelial growth factor, VEGF, is of particular interest because of …

Multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in
intensive care units. It is being encountered frequently in critically ill patients owing to …

Profound thrombocytopenia occurs in humans with sepsis and in mice administered
lipopolysaccharide (LPS). Growing evidence indicates that platelets may contribute to these …

The specific adhesive interaction between a non-spherical particle and a cell layer under a
linear shear flow is analyzed. The effect of the characteristic particle size, expressed in terms …

The binding of fluorescently labeled microspheres (FLMs, 0.1-μm diameter) coated with
antibody (1a29) to ICAM-1 was studied in postcapillary venules during topical application of …

Objective: To evaluate the expression and regulation of a novel B7‐like protein, PD‐L1, the
ligand for the immunoinhibitory receptor PD‐1 expressed on activated T‐cells, on …

In recent decades, it has become evident that the endothelium is by no means a passive
inner lining of blood vessels. This 'organ'with a large surface (∼ 350 m 2) and a …

A variety of recently discovered glycoproteins have been implicated in cell-cell interactions
that are critical for normal hemostasis, immune surveillance, and vascular wall integrity …