A major risk factor for Gaucher's disease is loss of function mutations in the GBA1 gene that
encodes lysosomal β-glucocerebrosidase, resulting in accumulation of glucosylceramide …

Fungi produce surface-active proteins, among which hydrophobins are the most
characterized and attractive also for their ability to form functional amyloids. Our most recent …

Misfolding and aggregation of tau protein, into pathological amyloids, are hallmarks of a
group of neurodegenerative diseases collectively termed tauopathies and their modulation …

The three GxxxG repeating motifs from the C‐terminal region of β‐amyloid (Aβ) peptide play
a significant role in regulating the aggregation kinetics of the peptide. Mutation of these …

The folding/misfolding of membrane-permiable Amyloid beta (Aβ) peptides is likely
associated with the advancing stage of Alzheimer's disease (AD) by disrupting Ca2+ …

A strict interplay is known to involve copper and zinc in many cellular processes. For this
reason, the results of copper's interaction with zinc binding proteins are of great interest. For …

The K-homology (KH) domains are small, structurally conserved domains found in proteins
of different origins characterized by a central conserved βααβ “core” and a GxxG motif in the …

The conformational conversion of the cellular prion protein (PrPC) into a misfolded,
aggregated and infectious scrapie isoform is associated with prion disease pathology and …

The structural effects of zinc replacement by xenobiotic metal ions have been widely studied
in several eukaryotic and prokaryotic zinc-finger-containing proteins. The prokaryotic zinc …

The protein MucR from Brucella abortus has been described as a transcriptional regulator of
many virulence genes. It is a member of the Ros/MucR family comprising proteins that …