BACKGROUND Uterine natural killer cells (uNK) are the most abundant lymphocytes found
in the decidua during implantation and in first trimester pregnancy. They are important for …

The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

Tissues are the new frontier of discoveries in immunology. Cells of the immune system are
an integral part of tissue physiology and immunity. Determining how immune cells inhabit …

Inflammatory bowel disease (IBD) has a peak age of diagnosis before the age of 35 years.
Concerns about infertility, adverse pregnancy outcomes, and heritability of IBD have …

The prevalence of obesity is increasingly common in the United States, with~ 25% of women
of reproductive age being overweight or obese. Metaflammation, a chronic low grade …

Uterine natural killer (uNK) cells are an immune subset located in the uterus. uNK cells have
distinct tissue-specific characteristics compared to their counterparts in peripheral blood and …

The presence of granulated lymphocytes in the human uterine mucosa, known as decidua
during pregnancy, or endometrium otherwise, was first noted in the nineteenth century, but it …

Uterine natural killer (uNK) cells constitute a unique uterine leucocyte subpopulation
facilitating implantation and maintaining pregnancy. Herein, we critically analyze current …

Estrogens, mainly 17β-estradiol (E2), play a critical role in reproductive organogenesis,
ovulation, and fertility via estrogen receptors. E2 is also a well-known regulator of utero …

In humans, balanced invasion of trophoblast cells into the uterine mucosa, the decidua, is
critical for successful pregnancy. Evidence suggests that this process is regulated by uterine …