Cardiac mechano-electric coupling: acute effects of mechanical stimulation on heart rate and rhythm

TA Quinn, P Kohl - Physiological reviews, 2021 - journals.physiology.org
The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Cardiac mechano-gated ion channels and arrhythmias

R Peyronnet, JM Nerbonne, P Kohl - Circulation research, 2016 - Am Heart Assoc
Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

[HTML][HTML] Myocardial tagging by cardiovascular magnetic resonance: evolution of techniques–pulse sequences, analysis algorithms, and applications

ESH Ibrahim - Journal of Cardiovascular Magnetic Resonance, 2011 - Elsevier
Cardiovascular magnetic resonance (CMR) tagging has been established as an essential
technique for measuring regional myocardial function. It allows quantification of local …

Ventricular arrhythmias in ischemic cardiomyopathy—New avenues for mechanism-guided treatment

M Amoni, E Dries, S Ingelaere, D Vermoortele… - Cells, 2021 - mdpi.com
Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Reperfused vs. nonreperfused myocardial infarction: when to use which model

ML Lindsey, LE de Castro Brás… - American Journal …, 2021 - journals.physiology.org
There is a lack of understanding in the cardiac remodeling field regarding the use of
nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This …

Feasibility of image-based simulation to estimate ablation target in human ventricular arrhythmia

H Ashikaga, H Arevalo, F Vadakkumpadan… - Heart Rhythm, 2013 - Elsevier
Background Previous studies suggest that magnetic resonance imaging with late
gadolinium enhancement (LGE) may identify slowly conducting tissues in scar-related …

RUNX1: an emerging therapeutic target for cardiovascular disease

A Riddell, M McBride, T Braun, SA Nicklin… - Cardiovascular …, 2020 - academic.oup.com
Abstract Runt-related transcription factor-1 (RUNX1), also known as acute myeloid
leukaemia 1 protein (AML1), is a member of the core-binding factor family of transcription …

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

M Frisk, M Ruud, EKS Espe, JM Aronsen… - Cardiovascular …, 2016 - academic.oup.com
Aims Invaginations of the cellular membrane called t-tubules are essential for maintaining
efficient excitation–contraction coupling in ventricular cardiomyocytes. Disruption of t-tubule …

Estimation of tissue contractility from cardiac cine-MRI using a biomechanical heart model

R Chabiniok, P Moireau, PF Lesault… - … and modeling in …, 2012 - Springer
The objective of this paper is to propose and assess an estimation procedure—based on
data assimilation principles—well suited to obtain some regional values of key biophysical …

The blinding period following ablation therapy for atrial fibrillation: proarrhythmic and antiarrhythmic pathophysiological mechanisms

LA Gottlieb, LRC Dekker, R Coronel - Clinical Electrophysiology, 2021 - jacc.org
Atrial fibrillation (AF) causes heart failure, ischemic strokes, and poor quality of life. The
number of patients with AF is estimated to increase to 18 million in Europe in 2050 …