CRISPR technologies for precise epigenome editing
The epigenome involves a complex set of cellular processes governing genomic activity.
Dissecting this complexity necessitates the development of tools capable of specifically …
Dissecting this complexity necessitates the development of tools capable of specifically …
The next generation of CRISPR–Cas technologies and applications
A Pickar-Oliver, CA Gersbach - Nature reviews Molecular cell biology, 2019 - nature.com
The prokaryote-derived CRISPR–Cas genome editing systems have transformed our ability
to manipulate, detect, image and annotate specific DNA and RNA sequences in living cells …
to manipulate, detect, image and annotate specific DNA and RNA sequences in living cells …
Long-range gene regulation in hormone-dependent cancer
The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …
territories to progressively smaller substructures, such as topologically associating domains …
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer
S Prekovic, K Schuurman, I Mayayo-Peralta… - Nature …, 2021 - nature.com
The glucocorticoid receptor (GR) regulates gene expression, governing aspects of
homeostasis, but is also involved in cancer. Pharmacological GR activation is frequently …
homeostasis, but is also involved in cancer. Pharmacological GR activation is frequently …
Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding
Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by
activating the transcription factor (TF) activity of glucocorticoid receptor (GR). Previous …
activating the transcription factor (TF) activity of glucocorticoid receptor (GR). Previous …
High-throughput screening of glucocorticoid-induced enhancer activity reveals mechanisms of stress-related psychiatric disorders
S Penner-Goeke, M Bothe, N Rek… - Proceedings of the …, 2023 - National Acad Sciences
Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic
insight into the genetic factors moderating the impact of stress can increase our …
insight into the genetic factors moderating the impact of stress can increase our …
[HTML][HTML] Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription
To infer potential causal relationships between 3D chromatin structure, enhancers, and
gene transcription, we mapped each feature in a genome-wide fashion across eight …
gene transcription, we mapped each feature in a genome-wide fashion across eight …
Intrinsic dynamics of a human gene reveal the basis of expression heterogeneity
Transcriptional regulation in metazoans occurs through long-range genomic contacts
between enhancers and promoters, and most genes are transcribed in episodic" bursts" of …
between enhancers and promoters, and most genes are transcribed in episodic" bursts" of …
The glucocorticoid receptor associates with the cohesin loader NIPBL to promote long-range gene regulation
The cohesin complex is central to chromatin looping, but mechanisms by which these long-
range chromatin interactions are formed and persist remain unclear. We demonstrate that …
range chromatin interactions are formed and persist remain unclear. We demonstrate that …
Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma
Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To
develop targeted treatments, it is important to understand the transcriptomic consequences …
develop targeted treatments, it is important to understand the transcriptomic consequences …