Transgenerational effects of early environmental insults on aging and disease incidence

M Ambeskovic, TJ Roseboom, GAS Metz - Neuroscience & Biobehavioral …, 2020 - Elsevier
Adverse early life experiences are major influences on developmental trajectories with
potentially life-long consequences. Prenatal or early postnatal exposure to stress …

[HTML][HTML] Aging, social distancing, and COVID-19 risk: Who is more vulnerable and why?

J Faraji, GAS Metz - Aging and disease, 2021 - ncbi.nlm.nih.gov
Perceived social support represents an important predictor of healthy aging. The global
COVID-19 pandemic has dramatically changed the face of social relationships and revealed …

Chronic traffic noise stress accelerates brain impairment and cognitive decline in mice

Z Jafari, BE Kolb, MH Mohajerani - Experimental neurology, 2018 - Elsevier
Although traffic noise exposure is a well-known environmental pollutant whose negative
health effect has been discussed in different aspects of the human life, only a few animal …

Why and how the early-life environment affects development of coping behaviours

MR Langenhof, J Komdeur - Behavioral Ecology and Sociobiology, 2018 - Springer
Understanding the ways in which individuals cope with threats, respond to challenges, make
use of opportunities and mediate the harmful effects of their surroundings is important for …

Social defeat stress during early adolescence confers resilience against a single episode of prolonged stress in adult rats

GF Mancini, E Marchetta, I Pignani, V Trezza… - Cells, 2021 - mdpi.com
Early-life adverse experiences (first hit) lead to coping strategies that may confer resilience
or vulnerability to later experienced stressful events (second hit) and the subsequent …

Non-diagnostic symptoms in a mouse model of autism in relation to neuroanatomy: the BTBR strain reinvestigated

J Faraji, M Karimi, C Lawrence, MH Mohajerani… - Translational …, 2018 - nature.com
Several mouse models of autism spectrum disorder (ASD), including the BTBR T+ tf/J
(BTBR) inbred strain, display a diverse array of behavioral deficits with particular face …

Ancestral stress alters lifetime mental health trajectories and cortical neuromorphology via epigenetic regulation

M Ambeskovic, O Babenko, Y Ilnytskyy, I Kovalchuk… - Scientific Reports, 2019 - nature.com
Experiences during early development are powerful determinants of lifetime mental health.
Here we investigated if ancestral stress regulates the brain's epigenetic memory to alter …

A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies

R Durand-de Cuttoli, FJ Martínez-Rivera, L Li… - Biological …, 2024 - Elsevier
Background Economic stress can serve as a second hit for people who have already
accumulated a history of adverse life experiences. How one recovers from a setback is a …

[HTML][HTML] Elemental analysis of hair provides biomarkers of maternal hardship linked to adverse behavioural outcomes in 4-year-old children: The QF2011 Queensland …

M Ambeskovic, DP Laplante, T Kenney… - Journal of Trace …, 2022 - Elsevier
Background Exposure to adverse experiences during pregnancy, such as a natural disaster,
can modify development of the child with potential long-term consequences. Elemental hair …

[HTML][HTML] Application of miRNA-seq in neuropsychiatry: A methodological perspective

D Pérez-Rodríguez, H López-Fernández… - Computers in Biology …, 2021 - Elsevier
MiRNAs are emerging as key molecules to study neuropsychiatric diseases. However,
despite the large number of methodologies and software for miRNA-seq analyses, there is …