Drugs that function through allosteric inhibition of kinase signaling represent a promising
approach for the targeted discovery of therapeutics. The majority of developed allosteric …

Regulators of G protein signalling (RGS) proteins are celebrating the 20th anniversary of
their discovery. The unveiling of this new family of negative regulators of G protein signalling …

PROteolysis TArgeting Chimeras (PROTACs) targeting the degradation of MEK have been
designed based on allosteric MEK inhibitors. Inhibition of the phosphorylation of ERK1/2 …

Constitutive JAK2 signaling is central to myeloproliferative neoplasm (MPN) pathogenesis
and results in activation of STAT, PI3K/AKT, and MEK/ERK signaling. However, the …

Wound healing is a complex process to restore skin. Plant-derived bioactive compounds
might be a source of substances for the treatment of wounds stalled in a non-resolving stage …

Cell migration is a critical process for wound healing, a physiological phenomenon needed
for proper skin restoration after injury. Wound healing can be compromised under …

The Mitogen-Activated Protein Kinase (MAPK) signaling pathway plays an important role in
cancer cell proliferation and survival. MAPKs' protein kinases MEK1/2 serve as important …

Protein kinases play a vital role in biology and deregulation of kinases is implicated in
numerous diseases ranging from cancer to neurodegenerative diseases, making them a …

Background Lymphocyte antigen 6 complex, locus K (LY6K) is a putative oncogene in
various cancers. Elevated expression of LY6K is correlated with poor patient prognosis in …

Vanicosides A and B are the esters of hydroxycinnamic acids with sucrose, occurring in a
few plant species from the Polygonaceae family. So far, vanicosides A and B have not been …