CD 8+ T cells provide an important component of protection against intracellular infections
and cancer. Immune responses by these T cells involve a primary phase of effector …

Human alphaherpesviruses including herpes simplex viruses (HSV-1, HSV-2) and varicella
zoster virus (VZV) establish persistent latent infection in sensory neurons for the life of the …

Loss of the endosomal anion transport protein ClC-5 impairs renal endocytosis and
underlies human Dent's disease. ClC-5 is thought to promote endocytosis by facilitating …

Autophagy is an important component of host innate and adaptive immunity to viruses. It is
critical for the degradation of intracellular pathogens and for promoting antigen presentation …

Gamma-interferon–inducible lysosomal thiolreductase (GILT) promotes major
histocompatibility complex (MHC) class II–restricted presentation of exogenous antigens …

DCs often require stimulation from CD4+ T cells to propagate CD8+ T cell responses, but
precisely how T cell help optimizes the priming capacity of DCs and why this appears to …

Neutralizing Abs play an important role for immunity against HSV-1 infection. This branch of
the immune response is initiated by MHC class II Ag presentation and activation of T cell …

ABSTRACT CD4 T cell activation during peripheral infections not only is essential in
inducing protective CD8 T cell memory but also promotes CD8 T cell function and survival …

Rapid induction of CD8+ cytotoxic T lymphocyte (CTL) responses is critical to combat acute
infection with intracellular pathogens. CD4+ T cells help prime antigen-specific CTLs in …

Abstract HSV-specific CD8+ T cells provide constant immunosurveillance of HSV-1 latently
infected neurons in sensory ganglia, and their functional properties are influenced by the …