Bone fractures are one of the most commonly occurring injuries of the musculoskeletal
system. A highly complex physiological process, fracture healing has been studied …

How mechanical forces influence the regeneration of bone remains an open question. Their
effect has been demonstrated experimentally, which has allowed mathematical theories of …

In recent decades, the field of bone mechanobiology has sought experimental techniques to
unravel the molecular mechanisms governing the phenomenon of mechanically regulated …

Background and objectives Early therapeutic exercises are vital for the healing of distal
radius fractures (DRFs) treated with the volar locking plate. However, current development of …

A timely restoration of the ruptured blood vessel network in order to deliver oxygen and
nutrients to the fracture zone is crucial for successful bone healing. Indeed, oxygen plays a …

Extrinsic mechanical signals have been implicated as key regulators of mesenchymal stem
cell (MSC) differentiation. It has been possible to test different hypotheses for mechano …

Bone fractures commonly repair by forming a bridging structure called callus, which begins
as soft tissue and gradually ossifies to restore rigidity to the bone. Virtual mechanical testing …

In the process of fracture healing, there are many cellular and molecular events that are
regulated by mechanical stimuli and biochemical signals. To explore the unknown …

Dynamization, increasing the interfragmentary movement (IFM) by reducing the fixation
stiffness from a rigid to a more flexible condition, is widely used clinically to promote fracture …

The outcome of secondary fracture healing processes is strongly influenced by
interfragmentary motion. Shear movement is assumed to be more disadvantageous than …