Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …

Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

The recent discovery of synaptic connections between neurons and brain tumor cells
fundamentally challenges our understanding of gliomas and brain metastases and shows …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in
synaptic transmission and plasticity. Both hyper‐and hypo‐activation of NMDARs are …

N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulators (PAMs) have
received increased interest as a powerful mechanism of action to provide relief as therapies …

Posttraumatic stress disorder (PTSD) is a serious psychosis leading to cognitive impairment.
To restore cognitive functions for patients, the main treatments are based on medication or …

NMDA receptors are part of the ionotropic glutamate receptor family, and are crucial for
neurotransmission and memory. At the cellular level, the effects of activating these receptors …

Cognitive impairments associated with schizophrenia (CIAS) represent a central element of
the symptomatology of this severe mental disorder. CIAS substantially determine the …

Different types of memory are thought to rely on different types of synaptic plasticity, many of
which depend on the activation of the N-Methyl-D Aspartate (NMDA) subtype of glutamate …