Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy

T Tomson, D Battino, R Bromley, S Kochen… - Epileptic …, 2019 - shs.cairn.info
Management of epilepsy in pregnancy: a report from the International League Against Epilepsy
Task Force on Women and Pregnancy | Cairn.info Cairn.info, Matières à réflexion Cairn.info …

Valproic acid and epilepsy: from molecular mechanisms to clinical evidences

M Romoli, P Mazzocchetti, R D'Alonzo… - Current …, 2019 - ingentaconnect.com
After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes

AA Veroniki, E Cogo, P Rios, SE Straus, Y Finkelstein… - BMC medicine, 2017 - Springer
Background Pregnant women with epilepsy frequently experience seizures related to
pregnancy complications and are often prescribed anti-epileptic drugs (AEDs) to manage …

Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug

T Tomson, D Battino, E Perucca - The Lancet Neurology, 2016 - thelancet.com
Since the serendipitous discovery of its anticonvulsant properties more than 50 years ago,
valproic acid has become established as an effective broad-spectrum antiepileptic drug that …

Practice guideline update summary: Pharmacologic treatment for pediatric migraine prevention: Report of the Guideline Development, Dissemination, and …

M Oskoui, T Pringsheim, L Billinghurst, S Potrebic… - Neurology, 2019 - AAN Enterprises
Objective To provide updated evidence-based recommendations for migraine prevention
using pharmacologic treatment with or without cognitive behavioral therapy in the pediatric …

Practice guideline update summary: Acute treatment of migraine in children and adolescents: Report of the Guideline Development, Dissemination, and …

M Oskoui, T Pringsheim, Y Holler-Managan… - Neurology, 2019 - AAN Enterprises
Objective To provide evidence-based recommendations for the acute symptomatic treatment
of children and adolescents with migraine. Methods We performed a systematic review of …

Teratogenicity of antiepileptic drugs

T Tomson, D Battino, E Perucca - Current opinion in neurology, 2019 - journals.lww.com
The risk of adverse fetal effects differs in relation to the type of AED and for some AEDs also
the daily dose. Although for MCMs the risk is primarily associated with the first trimester of …

Comparative safety of antiseizure medication monotherapy for major malformations

JM Cohen, S Alvestad, CE Cesta, MH Bjørk… - Annals of …, 2023 - Wiley Online Library
Objective This study was undertaken to examine the comparative safety of antiseizure
medication (ASM) monotherapy in pregnancy with respect to risk of major congenital …

Management of epilepsy in women

LJ Stephen, C Harden, T Tomson… - The Lancet Neurology, 2019 - thelancet.com
Epilepsy is a common neurological condition in women worldwide. Hormonal changes
occurring throughout a woman's life can influence and be influenced by seizure …

The placental barrier: the gate and the fate in drug distribution

N Tetro, S Moushaev, M Rubinchik-Stern… - Pharmaceutical …, 2018 - Springer
Optimal development of the embryo and the fetus depends on placental passage of gases,
nutrients, hormones, and waste products. These molecules are transferred across the …