A paradigm shift in imaging biomarkers in neovascular age-related macular degeneration

U Schmidt-Erfurth, SM Waldstein - Progress in Retinal and eye Research, 2016 - Elsevier
Neovascular age-related macular degeneration (AMD) has undergone substantial break-
throughs in diagnostic as well as therapeutic respect, with optical coherence tomography …

Neovascular macular degeneration: a review of etiology, risk factors, and recent advances in research and therapy

A Pugazhendhi, M Hubbell, P Jairam… - International Journal of …, 2021 - mdpi.com
Neovascular age-related macular degeneration (exudative or wet AMD) is a prevalent,
progressive retinal degenerative macular disease that is characterized by …

Age-related macular degeneration revisited–piecing the puzzle: the LXIX Edward Jackson memorial lecture

JW Miller - American journal of ophthalmology, 2013 - Elsevier
PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Nicotinamide ameliorates disease phenotypes in a human iPSC model of age-related macular degeneration

JS Saini, B Corneo, JD Miller, TR Kiehl, Q Wang… - Cell stem cell, 2017 - cell.com
Age-related macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell
monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the …

Pharmacogenetics for genes associated with age-related macular degeneration in the Comparison of AMD Treatments Trials (CATT)

SA Hagstrom, G Ying, GJT Pauer, GM Sturgill-Short… - Ophthalmology, 2013 - Elsevier
PURPOSE: To evaluate the pharmacogenetic relationship between genotypes of single
nucleotide polymorphisms (SNPs) known to be associated with age-related macular …

A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration

LD Orozco, LA Owen, J Hofmann, AD Stockwell, J Tao… - Cell genomics, 2023 - cell.com
Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …

Applications of microneedles in delivering drugs for various ocular diseases

P Gupta, KS Yadav - Life sciences, 2019 - Elsevier
Abstract Treatment of majority of eye diseases involve the use of eye drops or eye ointments,
which have major drawbacks of needing frequent administration, lower bioavailability and …

Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain

WJ Lukiw, PN Alexandrov - Molecular neurobiology, 2012 - Springer
Human brain cells rely on a specific subset of microRNAs (miRNAs or miRs) to shape their
gene expression patterns, and this is mediated through microRNA effects on messenger …

[HTML][HTML] Genome-wide meta-analysis identifies risk loci and improves disease prediction of age-related macular degeneration

W He, X Han, JS Ong, Y Wu, AW Hewitt, DA Mackey… - Ophthalmology, 2024 - Elsevier
Purpose To identify age-related macular degeneration (AMD) risk loci and to establish a
polygenic prediction model. Design Genome-wide association study (GWAS) and polygenic …

Oct and oct angiography update: Clinical application to age-related macular degeneration, central serous chorioretinopathy, macular telangiectasia, and diabetic …

L Zhang, EHC Van Dijk, E Borrelli, S Fragiotta… - Diagnostics, 2023 - mdpi.com
Similar to ultrasound adapting soundwaves to depict the inner structures and tissues, optical
coherence tomography (OCT) utilizes low coherence light waves to assess characteristics in …