Biological effects of indole-3-propionic acid, a gut microbiota-derived metabolite, and its precursor tryptophan in mammals' health and disease

P Konopelski, I Mogilnicka - International journal of molecular sciences, 2022 - mdpi.com
Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease

RM Chakaroun, LM Olsson, F Bäckhed - Nature Reviews Cardiology, 2023 - nature.com
Despite milestones in preventive measures and treatment, cardiovascular disease (CVD)
remains associated with a high burden of morbidity and mortality. The protracted nature of …

Gut microbially produced indole-3-propionic acid inhibits atherosclerosis by promoting reverse cholesterol transport and its deficiency is causally related to …

H Xue, X Chen, C Yu, Y Deng, Y Zhang… - Circulation …, 2022 - Am Heart Assoc
Background: Accumulating evidence has shown that disorders in the gut microbiota and
derived metabolites affect the development of atherosclerotic cardiovascular disease …

Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis

Z Fang, T Pan, L Li, H Wang, J Zhu, H Zhang… - Gut …, 2022 - Taylor & Francis
Gut microbial disturbance affects allergic diseases including asthma, atopic dermatitis (AD)
via the aberrant immune response. Some Bifidobacterial species and strains have been …

Gut microbial metabolites of aromatic amino acids as signals in host–microbe interplay

Y Liu, Y Hou, G Wang, X Zheng, H Hao - Trends in Endocrinology & …, 2020 - cell.com
Gut microbial metabolism is intimately coupled with host health and disease. Aromatic
amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may …

Kynurenine pathway in diabetes mellitus—novel pharmacological target?

K Kozieł, EM Urbanska - Cells, 2023 - mdpi.com
The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion
in the brain and in the periphery. Kynurenines display a wide range of biological actions …

Importance of gut microbiota metabolites in the development of cardiovascular diseases (CVD)

M Hemmati, S Kashanipoor, P Mazaheri, F Alibabaei… - Life Sciences, 2023 - Elsevier
Cardiovascular disease (CVD) remains the most common cause of death worldwide and
has become a public health concern. The proven notable risk factors for CVD are …

[HTML][HTML] Revisit gut microbiota and its impact on human health and disease

R Ding, WR Goh, R Wu, X Yue, X Luo… - Journal of food and drug …, 2019 - Elsevier
Trillions of microbes have evolved with and continue to live on human beings. With the rapid
advances in tools and technology in recent years, new knowledge and insight in cross-talk …

Aging microbiota-gut-brain axis in stroke risk and outcome

P Honarpisheh, RM Bryan, LD McCullough - Circulation research, 2022 - Am Heart Assoc
The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut
microbes and their host. Many environmental and host-related factors affect the gut …

Extensive summary of the important roles of indole propionic acid, a gut microbial metabolite in host health and disease

H Jiang, C Chen, J Gao - Nutrients, 2022 - mdpi.com
Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …