The integrin family, an indispensable part of cell-cell and cell-matrix interactions, consists of
a group of heterodimeric adhesion receptors formed by α-and β-integrin subunits. Their wide …

Sensing of pathogens by Toll-like receptor 4 (TLR4) induces an inflammatory response;
controlled responses confer immunity but uncontrolled responses cause harm. Here we …

Heterotrimeric G proteins (Gαβγ) are molecular switches that relay signals from 7-
transmembrane receptors located at the cell surface to the cytoplasm. The function of these …

The molecular mechanisms by which receptor tyrosine kinases (RTKs) and heterotrimeric G
proteins, two major signaling hubs in eukaryotes, independently relay signals across the …

Upon sensing DNA double-strand breaks (DSBs), eukaryotic cells either die or repair DSBs
via one of the two competing pathways, ie, non-homologous end-joining (NHEJ) or …

The structure, function, and dynamics of canonical activation of heterotrimeric G proteins by
the seven-transmembrane G protein-coupled receptors (GPCRs) have been illustrated in …

Objective: The aim of the present study was to explore the relationship among Girdin DNA
methylation, its high expression, and immune infiltration in human hepatocellular carcinoma …

Abstract Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone
marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease …

Kindlins are mechanosensitive adapter proteins that connect extracellular mechanical cues
to intracellular chemical events. Any alterations in these proteins thus alter cellular signaling …

Upon sensing DNA double-strand breaks (DSBs), eukaryotic cells either die or repair DSBs
via one of two competing pathways, ie, non-homologous end-joining (NHEJ) or homologous …